Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 2/20 | 0.57 |
| ▸ | PNMT | P11086 | 3/20 | 0.53 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.48 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29903194 | 1.00 | MELK (0.57) | MELKPNMTSLC2A1HDAC6ADRA2A | |
| SCHEMBL30924723 | 0.94 | F2 (0.54) | MELKSLC2A1HDAC6 | |
| SCHEMBL2734236 | 0.94 | F2 (0.54) | MELKSLC2A1HDAC6 | |
| SCHEMBL2732154 | 0.90 | MELK (0.58) | MELKSLC2A1HDAC6 | |
| SCHEMBL29903213 | 0.86 | HDAC6 (0.50) | HDAC6 | |
| SCHEMBL2728703 | 0.86 | HDAC6 (0.50) | HDAC6 | |
| SCHEMBL1014888 | 0.86 | MELK (0.56) | MELKPNMTSLC2A1ADRA2AADRA2B | |
| SCHEMBL29589725 | 0.81 | ALDH1A1 (0.59) | MELKPNMTADRA2AADRA2BADRA2C | |
| SCHEMBL1026913 | 0.81 | ALDH1A1 (0.59) | MELKPNMTADRA2AADRA2BADRA2C | |
| SCHEMBL1083199 | 0.81 | MELK (0.54) | MELKPNMTSLC2A1ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012117421-A1 | HISTONE DEACETYLASE INHIBITORS | ORCHID RESEARCH LABORATORIES LTD (IN) | 2012-09-07 | — | — | WO | claimed |
| EP-2274283-A1 | NOVEL N-SUBSTITUTED TETRAHYDROISOQUINOLINE/ISOINDOLINE HYDROXAMIC ACID COMPOUNDS | 4SC AG (DE) | 2011-01-19 | — | — | EP | claimed |