Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.54 |
| ▸ | PLG | P00747 | 1/20 | 0.54 |
| ▸ | PLAU | P00749 | 1/20 | 0.54 |
| ▸ | PLAT | P00750 | 1/20 | 0.54 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.54 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.54 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.53 |
| ▸ | MELK | Q14680 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30924723 | 1.00 | F2 (0.54) | F2PLGPLAUPLATKLKB1 | |
| SCHEMBL29903194 | 0.94 | MELK (0.57) | MELKHDAC6SLC2A1 | |
| SCHEMBL1029100 | 0.94 | MELK (0.57) | MELKHDAC6SLC2A1 | |
| SCHEMBL2732154 | 0.90 | MELK (0.58) | MELKHDAC6HDAC8SLC2A1 | |
| SCHEMBL29903213 | 0.86 | HDAC6 (0.50) | HDAC6HDAC8 | |
| SCHEMBL2728703 | 0.86 | HDAC6 (0.50) | HDAC6HDAC8 | |
| SCHEMBL31174276 | 0.86 | F2 (0.53) | F2PLGPLAUPLATKLKB1 | |
| SCHEMBL31174274 | 0.86 | F2 (0.53) | F2PLGPLAUPLATKLKB1 | |
| SCHEMBL4544259 | 0.82 | ASIC3 (0.47) | F2PLGPLAUPLATKLKB1 | |
| SCHEMBL1026101 | 0.81 | ALDH1A1 (0.59) | F2PLGPLAUPLATKLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445340-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | Millennium Pharmaceuticals, Inc. (US) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010151318-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-12-29 | — | — | WO | disclosed |
| WO-2010151318-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-12-29 | — | — | WO | disclosed |