SCHEMBL1029454

SCHEMBL1029454

Nc1[c]cc(Cl)cc1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL645101 0.71
SCHEMBL38194 0.71
SCHEMBL14775163 0.67
SCHEMBL1197678 0.67
SCHEMBL75548 0.67
SCHEMBL2984543 0.67
SCHEMBL22318 0.67
Benzene SCHEMBL8005678 0.67 TSHR (0.38)
SCHEMBL3285864 0.67
SCHEMBL193265 0.67

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 258 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4396348-A2 HIGH MOLECULAR WEIGHT MODIFIED DSRNA COMPOSITIONS Nanosur LLC (US) 2024-07-10 EP claimed
CN-118302524-A High molecular weight modified dsRNA compositions 纳诺索尔公司 2024-07-05 CN claimed
CN-116377458-A Method for electrochemically synthesizing quinazoline derivative 安徽科技学院 2023-07-04 CN claimed
WO-2023034849-A2 HIGH MOLECULAR WEIGHT MODIFIED dsRNA COMPOSITIONS nanoSUR LLC (US) 2023-03-09 WO claimed
US-10640769-B2 Post-transcriptionally chemically modified double strand RNAs nanoSUR LLC (US) 2020-05-05 US claimed
US-10556914-B2 Substituted isoxazolopyridazinones and isothiazolopyridazinones and methods of use ABBVIE INC. (US) 2020-02-11 US claimed
EP-3535274-A2 POST-TRANSCRIPTIONALLY CHEMICALLY MODIFIED DOUBLE STRAND RNAS Nanosur LLC (US) 2019-09-11 EP claimed
US-10294246-B2 Substituted boronic acids and boronate esters as immunoproteasome inhibitors MERCK PATENT GMBH (DE) 2019-05-21 US claimed
US-20190040389-A1 Post-Transcriptionally Chemically Modified Double Strand RNAs nanoSUR LLC 2019-02-07 US claimed
US-10131911-B2 Post-transcriptionally chemically modified double strand RNAs nanoSUR LLC (US) 2018-11-20 US claimed
US-6127381-A A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY LION BIOSCIENCE AG (DE) 2000-10-03 US claimed
WO-2000050406-A1 ISOQUINOLINE DERIVATIVES AND ISOQUINOLINE COMBINATORIAL LIBRARIES LION BIOSCIENCE AG (DE) 2000-08-31 WO claimed
WO-1999055679-A1 ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME TREGA BIOSCIENCES, INC. (US) 1999-11-04 WO claimed
EP-0863877-A4 ISOQUINOLINE DERIVATIVES AND ISOQUINOLINE COMBINATORIAL LIBRARIES TORREY PINES INST (US) 1999-07-21 EP claimed
US-5916899-A SOLID PHASE SYNTHESIS, REACTING PROTECTED AMINO ACID WITH SOLID SUPPORT; FORMING IMINE BY REACTION WITH ALDEHYDE, CYCLIZATION WITH ANHYDRIDE, CLEAVAGE AND DEPROTECTION. TREGA BIOSCIENCES, INC. (US) 1999-06-29 US claimed
US-5874443-A BIOSYNTHESIS TREGA BIOSCIENCES, INC. (US) 1999-02-23 US claimed
EP-0863877-A1 ISOQUINOLINE DERIVATIVES AND ISOQUINOLINE COMBINATORIAL LIBRARIES TORREY PINES INSTITUTE FOR MOLECULAR STUDIES (US) 1998-09-16 EP claimed
WO-1997016428-A1 ISOQUINOLINE DERIVATIVES AND ISOQUINOLINE COMBINATORIAL LIBRARIES TORREY PINES INSTITUTE FOR MOLECULAR STUDIES (US) 1997-05-09 WO claimed
EP-0273401-B1 ISOINDOLIN-1-ONE DERIVATIVE AND ANTIARRHYTHMIC AGENT KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) 1992-11-11 EP claimed
EP-0273401-A1 Isoindolin-1-one derivative and antiarrhythmic agent KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) 1988-07-06 EP claimed