Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | LDHA | P00338 | 2/20 | 0.47 |
| ▸ | LDHB | P07195 | 1/20 | 0.47 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10298077 | 0.84 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2TDP1LDHALDHB | |
| SCHEMBL611465 | 0.74 | KDM4C (0.67) | ALDH1A1SMN1; SMN2TDP1LDHALDHB | |
| SCHEMBL29388556 | 0.74 | KDM4C (0.67) | ALDH1A1SMN1; SMN2TDP1LDHALDHB | |
| SCHEMBL24989477 | 0.74 | KDM4C (0.55) | ALDH1A1SMN1; SMN2TDP1MAPTKDM4C | |
| SCHEMBL3462623 | 0.74 | MAPT (0.58) | ALDH1A1MAPTAKR1C3AKR1C2MEN1 | |
| SCHEMBL30473065 | 0.73 | KMT2A (0.64) | ALDH1A1SMN1; SMN2TDP1MAPTAKR1C3 | |
| SCHEMBL610622 | 0.73 | KMT2A (0.64) | ALDH1A1SMN1; SMN2TDP1MAPTAKR1C3 | |
| SCHEMBL609284 | 0.72 | MAPT (0.56) | ALDH1A1SMN1; SMN2TDP1LDHALDHB | |
| SCHEMBL29390925 | 0.72 | MAPT (0.56) | ALDH1A1SMN1; SMN2TDP1LDHALDHB | |
| SCHEMBL129889 | 0.72 | ALDH1A1 (0.69) | ALDH1A1SMN1; SMN2TDP1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8211878-B2 | Method for reducing neuronal death in nervous system injuries resulting from amyotrophic lateral sclerosis | NEUROTECH PHARMACEUTICALS CO., LTD. (KR) | 2012-07-03 | — | — | US | disclosed |
| US-8211877-B2 | Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system | NEUROTECH PHARMACEUTICALS CO., LTD. (KR) | 2012-07-03 | — | — | US | disclosed |
| US-20100331284-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR PREVENTING NEURODEGENERATION IN ACUTE AND CHRONIC INJURIES IN THE CENTRAL NERVOUS SYSTEM | NEUROTECH PHARMACEUTICALS CO., LTD. (KR) | 2010-12-30 | — | — | US | disclosed |
| US-20100323995-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR PREVENTING NEURODEGENERATION IN ACUTE AND CHRONIC INJURIES IN THE CENTRAL NERVOUS SYSTEM | NEUROTECH PHARMACEUTICALS CO., LTD. (KR) | 2010-12-23 | — | — | US | disclosed |
| US-7750045-B2 | Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system | NEUROTECH PHARMACEUTICALS CO., LTD. (KR) | 2010-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331284-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR PREVENTING NEURODEGENERATION IN ACUTE AND CHRONIC INJURIES IN THE CENTRAL NERVOUS SYSTEM | GRIK5, GRIN1, GRIN3A | ALDH1A1 762/4885SMN1; SMN2 79/4885TDP1 2057/4885 |
| US-20100323995-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR PREVENTING NEURODEGENERATION IN ACUTE AND CHRONIC INJURIES IN THE CENTRAL NERVOUS SYSTEM | GRIK5, GRIN1, GRIN3A | ALDH1A1 762/4885SMN1; SMN2 79/4885TDP1 2057/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.