Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 17/20 | 0.82 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1190762 | 1.00 | TRPM8 (0.82) | TRPM8RORCLMNAMAPTCNR1 | |
| SCHEMBL1098880 | 0.90 | TRPM8 (1.00) | TRPM8 | |
| SCHEMBL10299818 | 0.90 | TRPM8 (1.00) | TRPM8 | |
| SCHEMBL10299817 | 0.90 | TRPM8 (1.00) | TRPM8 | |
| SCHEMBL10299803 | 0.90 | TRPM8 (1.00) | TRPM8 | |
| SCHEMBL1098101 | 0.90 | TRPM8 (0.87) | TRPM8 | |
| SCHEMBL1100446 | 0.90 | TRPM8 (0.79) | TRPM8 | |
| SCHEMBL1100112 | 0.89 | TRPM8 (0.86) | TRPM8 | |
| SCHEMBL1100110 | 0.89 | TRPM8 (0.98) | TRPM8 | |
| SCHEMBL1099542 | 0.88 | TRPM8 (0.83) | TRPM8RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8216547-B2 | Radiolabelled TRP M8 receptor ligands | JANSSEN PHARMACEUTICA NV (BE) | 2012-07-10 | — | — | US | disclosed |
| US-20100015053-A1 | RADIOLABELLED TRP M8 RECEPTOR LIGANDS | JANSSEN PHARMACEUTICA NV (BE) | 2010-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100015053-A1 | RADIOLABELLED TRP M8 RECEPTOR LIGANDS | TRPM8, TRPM7, GPR68 | TRPM8 1/4885RORC 2200/4885LMNA 3395/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.