GPR68 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Ogerin (SCHEMBL29407423)	1.00	6/20
SCHEMBL9566454	0.64	6/20
SCHEMBL8413880	0.64	6/20
SCHEMBL14869452	0.58	6/20
SCHEMBL7754258	0.57	6/20
SCHEMBL30206799	0.56	6/20
SCHEMBL22261660	0.52	6/20
SCHEMBL29976032	0.52	6/20
SCHEMBL723446	0.48	6/20
SCHEMBL3301514	0.68	5/20
SCHEMBL6727019	0.68	5/20
Hydrochloric Acid (SCHEMBL9247173)	0.66	5/20
SCHEMBL197517	0.62	5/20
SCHEMBL8410920	0.59	5/20
SCHEMBL14869402	0.59	5/20
SCHEMBL14869439	0.59	5/20
SCHEMBL29609599	0.59	5/20
SCHEMBL14822066	0.57	5/20
SCHEMBL17840534	0.56	5/20
SCHEMBL4351104	0.56	5/20

Clinical trials — most relevant to GPR68 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell.	PHASE4	UNKNOWN
A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin	PHASE2	UNKNOWN
A Safety and Efficacy Study of Carbidopa-levodopa in Patients With Macular Degeneration	PHASE2	WITHDRAWN
Palmitoylethanolamide for Chronic Inflammatory Pain Conditions	PHASE2	RECRUITING
Dose Ranging Study of Carbidopa-levodopa	PHASE2	COMPLETED
Studying the Influence of LEAP2 on Integrated Endocrine Control of Eating During Semaglutide Treatment	PHASE1/PHASE2	RECRUITING
TRPM8 Activators for Peripheral Neuropathy	PHASE2	ACTIVE_NOT_RECRUITING
RP72 Monotherapy and in Combination With Gemcitabine in Patients With Pancreatic Cancer	PHASE1	UNKNOWN
Role of the Gut Sweet Taste Receptor in the Secretion of Satiation Peptides	PHASE1	COMPLETED
Role of the Gut Sweet Taste Receptor in the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
Sweet Taste Receptors and the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
to Assess the Safety of Ga68-Dolacga Injection in Healthy Volunteers	PHASE1	COMPLETED
Effect of GSK962040 on Oesophageal Function	PHASE1	COMPLETED
Assessment of [11C]ER176 to Image Translocator Protein in Brain and Whole Body of Healthy People	EARLY_PHASE1	COMPLETED
FFAR Agonist on Incretins, Insulin, Lipids and Inflammation	nan	COMPLETED
Dose-response Effect of Pine Nut Oil as a Dual FFA1 and FFA4 Agonist on Glucose Tolerance in Healthy Humans.	nan	COMPLETED
Neutrophil FFA2/GPR43 Receptor Expression in Patients With the Diagnosis of Sepsis	nan	WITHDRAWN
Colonic Propionate, Appetite, and Weight Loss	nan	COMPLETED
Effect of Dietary Oils as G-protein-coupled Receptor Agonists on Glucose Tolerance	nan	UNKNOWN
Exosomal microRNAs as a Biomarker in Panic Disorder and in Response to CBT	nan	UNKNOWN
Oat Bran and Plasma Lipid and Fecal Bacteria in Coronary Artery Disease Patients	nan	COMPLETED
Gastroparesis Registry 3	nan	COMPLETED
-Oleoyl Glycerol is a GPR119 Agonist and Signals GLP-1 Release in Humans.	nan	COMPLETED
Hyperlactacidemia in Major Abdominal Surgery and Monocarboxylate Receptors	nan	UNKNOWN
Development of Therapeutic Approaches Modulating Molecular Targets Implicated on Cancer Stem Cell-related Aggressiveness	nan	UNKNOWN
The Application of 68Ga-Pentixafor Alongside 68Ga-FAPI-04 PET/MR for Assessing Primary Aldosteronism.	nan	NOT_YET_RECRUITING
Study of [11C]DPA-713 for Temporal Lobe Epilepsy	nan	COMPLETED
Investigating Optimal Propionate Delivery to the Colon Using Stable Isotope Labeling	nan	COMPLETED
Effects of Probiotics on Gut Microbiota, Endocannabinoid and Immune Activation and Symptoms of Fatigue in Dancers	nan	COMPLETED
RCT to Describe the Effects of Colon Delivered Acetate, Propionate and Butyrate on Satiety and Glucose Homeostasis	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a GPR68 binder may also engage these)

Protein	Name	Similarity
O46685	—	1.000	O46685 →
Q8BFQ3	—	0.999	Q8BFQ3 →
Q8BUD0	—	0.998	Q8BUD0 →
GPR4	G-prodeshotein coupled receptor 4	0.993	landscape →
Q4KLH9	—	0.992	Q4KLH9 →
P50132	—	0.991	P50132 →
Q1JQB3	—	0.989	Q1JQB3 →
Q9Z282	—	0.988	Q9Z282 →
A0A4W3GG95	—	0.987	A0A4W3GG95 →
GPR132	Probable G-protein coupled receptor 132	0.986	landscape →
E7FEL0	—	0.983	E7FEL0 →
Q9GLX8	—	0.981	Q9GLX8 →
FFAR3	Free fatty acid receptor 3	0.978	landscape →
Q28642	—	0.977	Q28642 →
FFAR2	Free fatty acid receptor 2	0.977	landscape →
Q3UFD7	—	0.977	Q3UFD7 →
O15529	—	0.977	O15529 →
B2GV46	—	0.977	B2GV46 →
P25023	—	0.976	P25023 →
P32299	—	0.975	P32299 →
O70526	—	0.975	O70526 →
Q8C131	—	0.975	Q8C131 →
Q8VCK6	—	0.973	Q8VCK6 →
HCAR2	Hydroxycarboxylic acid receptor 2	0.973	landscape →
P31392	—	0.972	P31392 →
Q76EI6	—	0.972	Q76EI6 →
BDKRB2	B2 bradykinin receptor	0.971	landscape →
O88855	—	0.971	O88855 →
O00590	—	0.970	O00590 →
HCAR1	Hydroxycarboxylic acid receptor 1	0.970	landscape →