SCHEMBL10306367

SCHEMBL10306367

Cc1cccc(Cl)c1NC(=S)N/N=C/c1ccc(-c2ncn(-c3ccc(OC(F)(F)F)cc3)n2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.47
HTT P42858 1/20 0.47
ALOX12 P18054 1/20 0.44
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
BCHE P06276 2/20 0.40
MAPT P10636 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
MAOA P21397 3/20 0.39
MAOB P27338 3/20 0.39
CHRNA7 P36544 1/20 0.36
NPC1 O15118 1/20 0.35
MITF O75030 1/20 0.35
GAA P10253 1/20 0.35
RAB9A P51151 1/20 0.35
ACHE P22303 1/20 0.35
BACE1 P56817 1/20 0.35
RRM1 P23921 2/20 0.35
RRM2 P31350 2/20 0.35
RRM2B Q7LG56 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15153174 1.00 LMNA (0.47) LMNAHTTALOX12MEN1KMT2A
SCHEMBL11900037 0.94 LMNA (0.53) LMNAHTTALOX12MEN1KMT2A
SCHEMBL10306380 0.94 LMNA (0.53) LMNAHTTALOX12MEN1KMT2A
SCHEMBL10306331 0.94 LMNA (0.40) LMNAHTTALOX12MEN1KMT2A
SCHEMBL15153219 0.92 LMNA (0.39) LMNAHTTALOX12MEN1KMT2A
SCHEMBL15153222 0.92 LMNA (0.39) LMNAHTTALOX12MEN1KMT2A
SCHEMBL10306365 0.92 LMNA (0.38) LMNAHTTALOX12MEN1KMT2A
SCHEMBL10306403 0.91 LMNA (0.41) LMNAHTTALOX12MEN1KMT2A
SCHEMBL10306406 0.90 LMNA (0.39) LMNAHTTALOX12MEN1KMT2A
SCHEMBL10306375 0.90 LMNA (0.47) LMNAHTTALOX12MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160135464-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2016-05-19 US disclosed
US-9179681-B2 Pesticidal compositions DOW AGROSCIENCES LLC (US) 2015-11-10 US disclosed
US-9179681-B2 Pesticidal compositions DOW AGROSCIENCES LLC (US) 2015-11-10 US disclosed
EP-2461687-B1 PESTICIDAL COMPOSITIONS DOW AGROSCIENCES LLC (US) 2015-09-16 EP disclosed
US-8916183-B2 Pesticidal compositions and processes related thereto DOW AGROSCIENCES, LLC. (US) 2014-12-23 US disclosed
EP-2809160-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO Dow AgroSciences LLC (US) 2014-12-10 EP disclosed
US-20140148340-A1 PESTICIDAL COMPOSITIONS DOW AGROSCIENCES LLC (US) 2014-05-29 US disclosed
US-20140148340-A1 PESTICIDAL COMPOSITIONS DOW AGROSCIENCES LLC (US) 2014-05-29 US disclosed
US-8680269-B2 Pesticidal compositions DOW AGROSCIENCES, LLC. (US) 2014-03-25 US disclosed
US-8680269-B2 Pesticidal compositions DOW AGROSCIENCES, LLC. (US) 2014-03-25 US disclosed
WO-2013116053-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2013-08-08 WO disclosed
US-20130203592-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2013-08-08 US disclosed
US-20120172217-A1 PESTICIDAL COMPOSITIONS DOW AGROSCIENCES LLC (US) 2012-07-05 US disclosed
US-20120172217-A1 PESTICIDAL COMPOSITIONS DOW AGROSCIENCES LLC (US) 2012-07-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140148340-A1 PESTICIDAL COMPOSITIONS ACHE, DDT, PLCG2 LMNA 3489/4885HTT 3250/4885ALOX12 2356/4885
US-20160135464-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO CYP19A1, CYP1A1, AR LMNA 3954/4885HTT 2194/4885ALOX12 170/4885
US-20120172217-A1 PESTICIDAL COMPOSITIONS DDT, AADAC, ACHE LMNA 3885/4885HTT 786/4885ALOX12 3371/4885
US-20130203592-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO CYP19A1, CYP1A1, AR LMNA 3954/4885HTT 2194/4885ALOX12 170/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.