Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 7/20 | 0.56 |
| ▸ | DHFR | P00374 | 6/20 | 0.56 |
| ▸ | FOLR2 | P14207 | 1/20 | 0.47 |
| ▸ | FOLR1 | P15328 | 1/20 | 0.47 |
| ▸ | GART | P22102 | 1/20 | 0.47 |
| ▸ | ATIC | P31939 | 1/20 | 0.47 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.47 |
| ▸ | SLC19A1 | P41440 | 1/20 | 0.47 |
| ▸ | FRK | P42685 | 1/20 | 0.47 |
| ▸ | SLC46A1 | Q96NT5 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10306795 | 0.91 | TYMS (0.58) | TYMSDHFRFOLR2FOLR1GART | |
| SCHEMBL10306802 | 0.90 | DHFR (0.54) | TYMSDHFRFOLR2FOLR1GART | |
| SCHEMBL10306749 | 0.84 | DHFR (0.56) | TYMSDHFRFOLR2FOLR1GART | |
| SCHEMBL2610602 | 0.84 | TYMS (0.67) | TYMSDHFRFOLR2FOLR1GART | |
| Pemetrexed SCHEMBL7848273 | 0.80 | DHFR (0.83) | TYMSDHFRFOLR2FOLR1GART | |
| Pemetrexed SCHEMBL12022769 | 0.80 | DHFR (0.83) | TYMSDHFRFOLR2FOLR1GART | |
| SCHEMBL9046718 | 0.80 | TYMS (0.54) | TYMSDHFRFOLR2FOLR1GART | |
| SCHEMBL14329882 | 0.79 | DHFR (0.63) | TYMSDHFRFOLR2FOLR1GART | |
| SCHEMBL15247798 | 0.79 | NAMPT (0.52) | TYMSDHFRFOLR2FOLR1GART | |
| SCHEMBL14331358 | 0.79 | DHFR (0.72) | TYMSDHFRFOLR2FOLR1GART |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120172595-A1 | NOVEL PROCESS FOR THE SYNTHESIS OF PEMETREXED DISODIUM SALT | CHEMI S.P.A. (IT) | 2012-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120172595-A1 | NOVEL PROCESS FOR THE SYNTHESIS OF PEMETREXED DISODIUM SALT | PCNA, POLH, TYMP | TYMS 6/4885DHFR 51/4885FOLR2 129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.