Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 14/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 14/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10288587 | 0.90 | PIK3CD (0.49) | ALOX5PTGS2PIK3CDPIK3CBPIK3CA | |
| SCHEMBL10298356 | 0.85 | PIK3CD (0.60) | ALOX5PTGS2PIK3CDPIK3CBPIK3CA | |
| SCHEMBL622834 | 0.85 | PIK3CD (0.54) | ALOX5PIK3CDPIK3CBPIK3CACYP3A4 | |
| SCHEMBL10298363 | 0.85 | PIK3CD (0.59) | ALOX5PTGS2PIK3CDPIK3CBPIK3CA | |
| SCHEMBL10298347 | 0.83 | CETP (0.57) | PIK3CDPIK3CBPIK3CACYP3A4PIK3CG | |
| SCHEMBL10298711 | 0.83 | ALDH1A1 (0.51) | ALOX5PTGS2PIK3CAALDH1A1KDM4E | |
| SCHEMBL10298341 | 0.83 | PIK3CD (0.50) | ALOX5PTGS2PIK3CDPIK3CBPIK3CA | |
| SCHEMBL10308532 | 0.83 | ALOX5 (0.52) | ALOX5PTGS2PIK3CDPIK3CBPIK3CA | |
| SCHEMBL10006011 | 0.81 | PIK3CD (0.55) | ALOX5PIK3CDPIK3CBPIK3CACYP3A4 | |
| SCHEMBL10298349 | 0.80 | PIK3CD (0.57) | ALOX5PTGS2PIK3CDPIK3CBPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150175563-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARM INC (US) | 2015-06-25 | — | — | US | disclosed |
| US-20150175593-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARM INC (US) | 2015-06-25 | — | — | US | disclosed |
| US-8796271-B2 | Heteroaryls and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-08-05 | — | — | US | disclosed |
| US-8796268-B2 | Heteroaryls and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-08-05 | — | — | US | disclosed |
| US-20120178723-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150175563-A1 | HETEROARYLS AND USES THEREOF | PIK3R1, PIK3R2, PIK3R3 | ALOX5 524/4885PTGS2 669/4885PIK3CD 18/4885 |
| US-20120178723-A1 | HETEROARYLS AND USES THEREOF | PIK3R1, PIK3R2, PIK3R3 | ALOX5 302/4885PTGS2 601/4885PIK3CD 19/4885 |
| US-20150175593-A1 | HETEROARYLS AND USES THEREOF | PIK3R1, PIK3R2, PIK3R3 | ALOX5 302/4885PTGS2 601/4885PIK3CD 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.