Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 6/20 | 0.56 |
| ▸ | HEXA | P06865 | 1/20 | 0.56 |
| ▸ | HEXB | P07686 | 1/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | GMNN | O75496 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12496375 | 0.90 | ADORA2A (0.52) | DHFRHEXAHEXBADORA2AADORA1 | |
| SCHEMBL7162150 | 0.85 | DHFR (0.66) | DHFRHEXAHEXBADORA2AADORA1 | |
| SCHEMBL13402261 | 0.81 | MAPK1 (0.43) | DHFRHEXAHEXBADORA2AADORA1 | |
| Methane SCHEMBL11818737 | 0.79 | HEXA (0.57) | DHFRHEXAHEXBADORA2AADORA1 | |
| SCHEMBL2473930 | 0.78 | DHFR (0.58) | DHFRHEXAHEXBADORA2AADORA1 | |
| SCHEMBL16540957 | 0.77 | L3MBTL1 (0.45) | DHFRHEXAHEXBADORA2AADORA1 | |
| SCHEMBL16540959 | 0.77 | POLB (0.46) | DHFRHEXAHEXBADORA2AADORA1 | |
| SCHEMBL3500167 | 0.76 | DHFR (0.61) | DHFRHEXAHEXBADORA2AKDM4E | |
| Hydrochloric Acid SCHEMBL15487768 | 0.76 | DHFR (0.56) | DHFRHEXAHEXBADORA2AADORA1 | |
| SCHEMBL27631682 | 0.74 | ADORA1 (0.61) | DHFRHEXAHEXBADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1805966-B | Pyrimidine compounds having phosphonate groups as antiviral nucleotide analogs | INST OF ORGANIC CHENISTRY AND | 2013-03-13 | — | — | CN | disclosed |
| EP-1644389-B1 | PYRIMIDINE COMPOUNDS HAVING PHOSPHONATE GROUPS AS ANTIVIRAL NUCLEOTIDE ANALOGS | ACAD OF SCIENCE CZECH REPUBLIC (CZ) | 2011-01-19 | — | — | EP | disclosed |
| US-20060241081-A1 | Novel compounds and methods for therapy | INSTITUTE OF ORGANIC CHEMISTRY | 2006-10-26 | — | — | US | disclosed |
| US-7115592-B2 | Phosphonate substituted pyrimidine compounds and methods for therapy | INSTITUTE OF ORGANIC CHEMISTRY (CZ) | 2006-10-03 | — | — | US | disclosed |
| EP-1644389-A1 | PYRIMIDINE COMPOUNDS HAVING PHOSPHONATE GROUPS AS ANTIVIRAL NUCLEOTIDE ANALOGS | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 2006-04-12 | — | — | EP | disclosed |
| US-20050075318-A1 | Novel compounds and methods for therapy | INSTITUTE OF ORGANIC CHENISTRY AND BIOCHEMISTRY ACADEMYOF SCIENCES OF THE CZECH REPUBLIC | 2005-04-07 | — | — | US | disclosed |
| WO-2004111064-A1 | PYRIMIDINE COMPOUNDS HAVING PHOSPHONATE GROUPS AS ANTIVIRAL NUCLEOTIDE ANALOGS | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY, ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 2004-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050075318-A1 | Novel compounds and methods for therapy | ZC3HAV1, IFNAR1, EIF2AK2 | DHFR 72/4885HEXA 1925/4885HEXB 1621/4885 |
| US-20060241081-A1 | Novel compounds and methods for therapy | ZC3HAV1, IFNAR1, EIF2AK2 | DHFR 72/4885HEXA 1925/4885HEXB 1621/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.