Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | FPR2 | P25090 | 1/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1031344 | 1.00 | RAB9A (0.43) | RAB9APOLBHTTNPSR1ALDH1A1 | |
| SCHEMBL1030180 | 0.77 | POLB (0.51) | RAB9APOLBHTTNPSR1ALDH1A1 | |
| SCHEMBL1030181 | 0.77 | POLB (0.51) | RAB9APOLBHTTNPSR1ALDH1A1 | |
| SCHEMBL1012695 | 0.76 | BTK (0.47) | NFKB1NFKB2RELAKMT2AKDM1A | |
| SCHEMBL13678772 | 0.76 | BTK (0.47) | NFKB1NFKB2RELAKMT2AKDM1A | |
| SCHEMBL1030494 | 0.76 | BTK (0.47) | NFKB1NFKB2RELAKMT2AKDM1A | |
| SCHEMBL1027576 | 0.75 | HTT (0.64) | RAB9APOLBHTTNPSR1ALDH1A1 | |
| SCHEMBL1026891 | 0.75 | HTT (0.64) | RAB9APOLBHTTNPSR1ALDH1A1 | |
| SCHEMBL14239951 | 0.75 | NFKB1 (0.40) | NFKB1NFKB2RELACCR1KDM1A | |
| SCHEMBL1030042 | 0.75 | NFKB1 (0.40) | NFKB1NFKB2RELACCR1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814855-B1 | DICARBOXAMIDE DERIVATIVES AND THEIR USE AS FACTOR XA INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-01-19 | — | — | EP | disclosed |
| US-20090270360-A1 | DICARBOXAMIDE DERIVATIVES | BOEHRINGER MARKUS | 2009-10-29 | — | — | US | disclosed |
| US-7501413-B2 | Dicarboxamide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-03-10 | — | — | US | disclosed |
| US-20060106016-A1 | Dicarboxamide derivatives | HOFFMANN-LA ROCHE INC. | 2006-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060106016-A1 | Dicarboxamide derivatives | F2, F12, TFPI | RAB9A 2494/4885POLB 3769/4885HTT 4761/4885 |
| US-20090270360-A1 | DICARBOXAMIDE DERIVATIVES | F2, F12, TFPI | RAB9A 2494/4885POLB 3769/4885HTT 4761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.