Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 4/20 | 0.51 |
| ▸ | CNR2 | P34972 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1032620 | 0.84 | HTT (0.53) | HTTPOLBCNR2LMNAMAPT | |
| SCHEMBL1028177 | 0.84 | CNR2 (0.48) | POLBCNR2LMNAMAPTSMN1; SMN2 | |
| SCHEMBL1031812 | 0.81 | HPGD (0.49) | HTTPOLBCNR2LMNAMAPT | |
| SCHEMBL1029485 | 0.80 | HSD11B1 (0.46) | CNR2ALDH1A1CNR1 | |
| SCHEMBL1031603 | 0.79 | CNR2 (0.47) | HTTPOLBCNR2LMNAMAPT | |
| SCHEMBL1029042 | 0.78 | LMNA (0.44) | HTTPOLBCNR2LMNAMAPT | |
| SCHEMBL1032537 | 0.78 | CNR2 (0.53) | CNR2SMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL1028758 | 0.77 | GRIN2B (0.44) | CNR2MAPTSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL1031174 | 0.77 | CNR2 (0.39) | POLBCNR2LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL1027171 | 0.76 | SMN1; SMN2 (0.45) | POLBCNR2LMNASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035375-B1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2011-01-19 | — | — | EP | claimed |
| EP-2035375-B1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2011-01-19 | — | — | EP | disclosed |