Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | AXL | P30530 | 5/20 | 0.40 |
| ▸ | KDR | P35968 | 4/20 | 0.37 |
| ▸ | SLC18A3 | Q16572 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15329344 | 0.82 | SIGMAR1 (0.43) | KDM4ESLC18A3ALDH1A1MAPT | |
| SCHEMBL4993845 | 0.75 | KMT2A (0.51) | KMT2APKMKDM4EAXLKDR | |
| SCHEMBL4993854 | 0.75 | KMT2A (0.51) | KMT2APKMKDM4EAXLKDR | |
| SCHEMBL11315406 | 0.75 | KDM4E (0.57) | KMT2APKMKDM4EAXLKDR | |
| SCHEMBL17166950 | 0.75 | KDM4E (0.57) | KMT2APKMKDM4EAXLKDR | |
| SCHEMBL13698447 | 0.75 | KDM4E (0.57) | KMT2APKMKDM4EAXLKDR | |
| SCHEMBL4989928 | 0.74 | KMT2A (0.44) | KMT2APKMKDM4EAXLKDR | |
| SCHEMBL14090626 | 0.74 | KMT2A (0.44) | KMT2APKMKDM4EAXLKDR | |
| SCHEMBL11321364 | 0.74 | KMT2A (0.44) | KMT2APKMKDM4EAXLKDR | |
| SCHEMBL15759153 | 0.68 | KMT2A (0.56) | KMT2APKMKDM4EAXLKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2476679-A2 | Substituted triazoles useful as AXL inhibitors | Rigel Pharmaceuticals, Inc. (US) | 2012-07-18 | — | — | EP | disclosed |