Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | MGLL | Q99685 | 2/20 | 0.40 |
| ▸ | ESRRG | P62508 | 5/20 | 0.40 |
| ▸ | ESR1 | P03372 | 4/20 | 0.40 |
| ▸ | ESRRA | P11474 | 2/20 | 0.40 |
| ▸ | ESRRB | O95718 | 3/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.38 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.38 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10316692 | 0.82 | KMT2A (0.45) | KDM4EALDH1A1SLC18A3MAPT | |
| SCHEMBL10316678 | 0.77 | PDCD1 (0.39) | MGLLL3MBTL1ALDH1A1HRH3MBTD1 | |
| SCHEMBL931188 | 0.72 | MAPT (0.44) | SIGMAR1MGLLESRRGESR1ESRRA | |
| SCHEMBL931189 | 0.72 | MAPT (0.44) | SIGMAR1MGLLESRRGESR1ESRRA | |
| SCHEMBL22848097 | 0.71 | L3MBTL3 (0.70) | SIGMAR1GRIN2BL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL22848095 | 0.71 | L3MBTL3 (0.70) | SIGMAR1GRIN2BL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL8584491 | 0.71 | L3MBTL3 (0.70) | SIGMAR1GRIN2BL3MBTL1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL8814411 | 0.69 | L3MBTL3 (0.68) | SIGMAR1ESRRGESR1ESRRAESRRB | |
| SCHEMBL13648726 | 0.69 | L3MBTL3 (0.72) | SIGMAR1GRIN2BL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL3955460 | 0.69 | LTA4H (0.54) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8809347-B2 | Bicyclic aryl and bicyclic heteroaryl substituted triazoles useful as AXL inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2014-08-19 | — | — | US | disclosed |
| US-20130281468-A1 | BICYCLIC ARYL AND BICYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS | MIDCAP FINANCIAL TRUST | 2013-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130281468-A1 | BICYCLIC ARYL AND BICYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS | AXL, TYRO3, ERBB2 | SIGMAR1 3378/4885MGLL 2643/4885ESRRG 778/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.