Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 15/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 15/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13390970 | 0.92 | TP53 (0.32) | HCRTR2 | |
| SCHEMBL4440477 | 0.87 | KEAP1 (0.35) | KEAP1NFE2L2 | |
| SCHEMBL3299707 | 0.86 | — | — | |
| SCHEMBL3304036 | 0.84 | KEAP1 (0.41) | KEAP1NFE2L2HCRTR2PPARGHSP90AA1 | |
| SCHEMBL3297441 | 0.81 | KEAP1 (0.35) | KEAP1NFE2L2 | |
| SCHEMBL3297803 | 0.81 | KEAP1 (0.35) | KEAP1NFE2L2 | |
| SCHEMBL4432623 | 0.81 | KEAP1 (0.35) | KEAP1NFE2L2 | |
| SCHEMBL13391160 | 0.80 | ROCK1 (0.35) | KEAP1NFE2L2 | |
| SCHEMBL3299475 | 0.80 | KDM4C (0.37) | KEAP1NFE2L2 | |
| SCHEMBL4428677 | 0.80 | KEAP1 (0.34) | KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121600-B1 | SUBSTITUTED ARYLSULPHONYLGLYCINES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INT (DE) | 2012-07-18 | — | — | EP | disclosed |