Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 13/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 13/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3299475 | 0.89 | KDM4C (0.37) | KEAP1NFE2L2ALDH1A1L3MBTL1 | |
| SCHEMBL13391160 | 0.89 | ROCK1 (0.35) | KEAP1NFE2L2ALDH1A1L3MBTL1PLAU | |
| SCHEMBL3304036 | 0.89 | KEAP1 (0.41) | KEAP1NFE2L2SMN1; SMN2 | |
| SCHEMBL13390768 | 0.88 | PKM (0.34) | — | |
| SCHEMBL3294548 | 0.88 | KEAP1 (0.37) | KEAP1NFE2L2SMN1; SMN2 | |
| SCHEMBL4432623 | 0.88 | KEAP1 (0.35) | KEAP1NFE2L2ALDH1A1SMN1; SMN2 | |
| SCHEMBL13391273 | 0.88 | F2 (0.34) | KEAP1NFE2L2ALDH1A1PLAU | |
| SCHEMBL3297803 | 0.88 | KEAP1 (0.35) | KEAP1NFE2L2SMN1; SMN2 | |
| SCHEMBL4441320 | 0.88 | KEAP1 (0.34) | KEAP1NFE2L2ALDH1A1L3MBTL1PLAU | |
| SCHEMBL10357252 | 0.87 | ALDH1A1 (0.39) | KEAP1NFE2L2ALDH1A1L3MBTL1PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121600-B1 | SUBSTITUTED ARYLSULPHONYLGLYCINES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INT (DE) | 2012-07-18 | — | — | EP | disclosed |
| EP-2121600-A2 | SUBSTITUTED ARYLSULPHONYLGLYCINES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS | Boehringer Ingelheim International GmbH (DE) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008099000-A2 | SUBSTITUTED ARYLSULPHONYLGLYCINES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-08-21 | — | — | WO | disclosed |