Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 11/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.48 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1591224 | 0.83 | FFAR1 (0.56) | PGRFFAR1FFAR4NR3C1AR | |
| SCHEMBL1590907 | 0.76 | PGR (0.58) | PGRFFAR1FFAR4NR3C1AR | |
| SCHEMBL1591670 | 0.76 | AXL (0.49) | PGRNR3C1ARESR2KDM4E | |
| SCHEMBL1591088 | 0.75 | PGR (0.60) | PGRFFAR1FFAR4BRAFALDH1A1 | |
| SCHEMBL1591137 | 0.74 | PGR (0.50) | PGRFFAR1FFAR4BRAFKDM4E | |
| SCHEMBL1592031 | 0.74 | AXL (0.47) | — | |
| SCHEMBL1591383 | 0.73 | AXL (0.48) | — | |
| SCHEMBL1592072 | 0.72 | PGR (0.55) | PGRFFAR1FFAR4ATM | |
| SCHEMBL1592197 | 0.72 | RORC (0.51) | PGRFFAR1FFAR4BRAFALDH1A1 | |
| SCHEMBL4203669 | 0.71 | PGR (0.96) | PGRFFAR1FFAR4ARALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262772-B1 | QUINOLINE DERIVATIVES AS AXL KINASE INHIBITORS | MAX PLANCK GESELLSCHAFT (DE) | 2012-07-18 | — | — | EP | claimed |