Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | RXRA | P19793 | 2/20 | 0.35 |
| ▸ | RXRB | P28702 | 2/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3298104 | 0.89 | POLB (0.37) | POLBHTTNPSR1LMNATP53 | |
| SCHEMBL3302811 | 0.89 | POLB (0.37) | POLBHTTNPSR1LMNATP53 | |
| SCHEMBL10316823 | 0.89 | KEAP1 (0.39) | POLBHTTNPSR1LMNATP53 | |
| Hydrochloric Acid SCHEMBL3297336 | 0.88 | POLB (0.36) | POLBHTTNPSR1LMNATP53 | |
| SCHEMBL13390174 | 0.87 | GPR119 (0.37) | POLBHTTNPSR1LMNATP53 | |
| SCHEMBL13391394 | 0.86 | POLB (0.35) | POLBHTTNPSR1LMNATP53 | |
| SCHEMBL10317000 | 0.83 | HTT (0.42) | POLBHTTNPSR1LMNATP53 | |
| SCHEMBL4429616 | 0.83 | POLB (0.40) | POLBHTTNPSR1LMNATP53 | |
| SCHEMBL13391395 | 0.83 | HTT (0.34) | POLBHTTNPSR1LMNATP53 | |
| Hydrochloric Acid SCHEMBL3300321 | 0.83 | POLB (0.40) | POLBHTTNPSR1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121600-B1 | SUBSTITUTED ARYLSULPHONYLGLYCINES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INT (DE) | 2012-07-18 | — | — | EP | disclosed |