Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 12/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 12/20 | 0.33 |
| ▸ | F2 | P00734 | 4/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3299977 | 0.91 | KEAP1 (0.34) | KEAP1NFE2L2F2LMNAPOLB | |
| SCHEMBL3297803 | 0.90 | KEAP1 (0.35) | KEAP1NFE2L2F2 | |
| SCHEMBL10317260 | 0.89 | KEAP1 (0.33) | KEAP1NFE2L2F2HCRTR2MAPT | |
| SCHEMBL3302993 | 0.89 | KEAP1 (0.36) | KEAP1NFE2L2F2 | |
| SCHEMBL3300833 | 0.88 | KEAP1 (0.36) | KEAP1NFE2L2F2 | |
| SCHEMBL3297441 | 0.88 | KEAP1 (0.35) | KEAP1NFE2L2F2 | |
| SCHEMBL3299475 | 0.88 | KDM4C (0.37) | KEAP1NFE2L2F2 | |
| SCHEMBL3299234 | 0.86 | KDM5A (0.37) | KEAP1NFE2L2LMNAMAPT | |
| SCHEMBL3300257 | 0.86 | ROCK1 (0.36) | KEAP1NFE2L2F2 | |
| SCHEMBL10317933 | 0.85 | HCRTR2 (0.35) | KEAP1NFE2L2LMNAPOLBHCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121600-B1 | SUBSTITUTED ARYLSULPHONYLGLYCINES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INT (DE) | 2012-07-18 | — | — | EP | disclosed |