Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 9/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 9/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | DAGLB | Q8NCG7 | 1/20 | 0.32 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10317260 | 0.85 | KEAP1 (0.33) | HCRTR2KEAP1NFE2L2 | |
| SCHEMBL10318853 | 0.85 | KEAP1 (0.33) | HCRTR2KEAP1NFE2L2LMNAPOLB | |
| SCHEMBL4432255 | 0.84 | KEAP1 (0.39) | HCRTR2KEAP1NFE2L2ALDH1A1L3MBTL1 | |
| SCHEMBL4439401 | 0.84 | PTK2 (0.44) | KEAP1NFE2L2LMNA | |
| SCHEMBL14107692 | 0.83 | L3MBTL1 (0.38) | HCRTR2KEAP1NFE2L2ALDH1A1L3MBTL1 | |
| SCHEMBL13391292 | 0.81 | HPGD (0.34) | KEAP1NFE2L2LMNAPOLBALDH1A1 | |
| SCHEMBL3303303 | 0.80 | ALDH1A1 (0.35) | KEAP1NFE2L2ALDH1A1L3MBTL1DAGLB | |
| SCHEMBL10357252 | 0.80 | ALDH1A1 (0.39) | KEAP1NFE2L2ALDH1A1L3MBTL1 | |
| SCHEMBL3297301 | 0.80 | KEAP1 (0.35) | KEAP1NFE2L2ALDH1A1L3MBTL1 | |
| SCHEMBL3301095 | 0.79 | KEAP1 (0.37) | HCRTR2KEAP1NFE2L2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121600-B1 | SUBSTITUTED ARYLSULPHONYLGLYCINES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INT (DE) | 2012-07-18 | — | — | EP | disclosed |