Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | EP300 | Q09472 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | BCL2 | P10415 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | BCL2L1 | Q07817 | 4/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.35 |
| ▸ | BCL2A1 | Q16548 | 4/20 | 0.35 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1748908 | 0.80 | GCGR (0.43) | BCL2 | |
| SCHEMBL2637730 | 0.77 | GRIA2 (0.45) | RAB9ANPC1TP53MDM2MAPT | |
| SCHEMBL1031754 | 0.75 | KDM4E (0.52) | RAB9ANPC1TDP1MAPTMEN1 | |
| SCHEMBL1031856 | 0.74 | BCL2 (0.35) | TP53MDM2MAPTEP300BCL2 | |
| SCHEMBL1031707 | 0.73 | POLB (0.46) | TP53MDM2MAPTBCL2MEN1 | |
| SCHEMBL1031726 | 0.73 | KDM4E (0.49) | RAB9ANPC1MAPTMEN1KMT2A | |
| SCHEMBL1030036 | 0.73 | HSP90AA1 (0.38) | TDP1MAPTKMT2A | |
| SCHEMBL1030744 | 0.72 | POLB (0.47) | TP53MAPTBCL2MEN1KMT2A | |
| SCHEMBL1031910 | 0.70 | NPC1 (0.59) | RAB9ANPC1MEN1KMT2A | |
| SCHEMBL1031266 | 0.70 | CCR1 (0.44) | TDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035375-B1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2011-01-19 | — | — | EP | claimed |