Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 15/20 | 0.43 |
| ▸ | GCG | P01275 | 3/20 | 0.41 |
| ▸ | BCL2 | P10415 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1031856 | 0.85 | BCL2 (0.35) | GCGRBCL2 | |
| SCHEMBL2637730 | 0.81 | GRIA2 (0.45) | — | |
| SCHEMBL1032074 | 0.80 | RAB9A (0.39) | BCL2 | |
| SCHEMBL1031726 | 0.79 | KDM4E (0.49) | NPSR1 | |
| SCHEMBL1031754 | 0.77 | KDM4E (0.52) | — | |
| SCHEMBL1031069 | 0.76 | PDE10A (0.43) | — | |
| SCHEMBL1031910 | 0.76 | NPC1 (0.59) | — | |
| SCHEMBL1031707 | 0.75 | POLB (0.46) | BCL2NPSR1 | |
| SCHEMBL1030744 | 0.73 | POLB (0.47) | BCL2NPSR1 | |
| SCHEMBL1028545 | 0.73 | ROCK2 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7968591-B2 | 1,3-disubstituted 4-methyl-1H-pyrrole-2-carboxamides and their use in medicaments | GRUENENTHAL GMBH (DE) | 2011-06-28 | — | — | US | disclosed |
| US-20090137573-A1 | 1,3-Disubstituted 4-methyl-1H-pyrrole-2-carboxamides and their Use in Medicaments | GRUENENTHAL GMBH (DE) | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137573-A1 | 1,3-Disubstituted 4-methyl-1H-pyrrole-2-carboxamides and their Use in Medicaments | OPRL1, TPH1, OPRK1 | GCGR 748/4885GCG 4141/4885BCL2 2474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.