Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 4/20 | 0.41 |
| ▸ | RAD52 | P43351 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MDM4 | O15151 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1030744 | 0.94 | POLB (0.47) | POLBALDH1A1LMNAKDM4EHPGD | |
| SCHEMBL1032354 | 0.78 | ALDH1A1 (0.44) | POLBALDH1A1LMNAKDM4EHPGD | |
| SCHEMBL1031848 | 0.77 | RAB9A (0.53) | POLBALDH1A1LMNAHPGDKMT2A | |
| SCHEMBL1032566 | 0.76 | AURKA (0.47) | POLBALDH1A1LMNAKDM4EKMT2A | |
| SCHEMBL1748908 | 0.75 | GCGR (0.43) | NPSR1BCL2 | |
| SCHEMBL1032074 | 0.73 | RAB9A (0.39) | KMT2AMAPTMEN1TP53MDM2 | |
| SCHEMBL1027640 | 0.72 | GAA (0.35) | POLBKMT2AMAPTMEN1RAD52 | |
| SCHEMBL1031266 | 0.71 | CCR1 (0.44) | KMT2AMEN1GAACYP2C19 | |
| SCHEMBL1031726 | 0.69 | KDM4E (0.49) | POLBALDH1A1KDM4EHPGDKMT2A | |
| SCHEMBL1029785 | 0.67 | LMNA (0.51) | POLBALDH1A1LMNAKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035375-B1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2011-01-19 | — | — | EP | claimed |