Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | ASPH | Q12797 | 3/20 | 0.56 |
| ▸ | KDM8 | Q8N371 | 3/20 | 0.56 |
| ▸ | RIOX2 | Q8IUF8 | 2/20 | 0.56 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.52 |
| ▸ | KDM6B | O15054 | 1/20 | 0.52 |
| ▸ | KDM4A | O75164 | 1/20 | 0.52 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.52 |
| ▸ | JAK3 | P52333 | 2/20 | 0.51 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | JAK1 | P23458 | 1/20 | 0.51 |
| ▸ | TYK2 | P29597 | 1/20 | 0.51 |
| ▸ | VNN1 | O95497 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22140403 | 0.91 | JAK3 (0.50) | KDM4EASPHKDM8RIOX2KDM4C | |
| SCHEMBL10330658 | 0.82 | KDM4E (0.60) | KDM4EASPHKDM8RIOX2KDM4C | |
| SCHEMBL4409419 | 0.80 | KDM4E (0.60) | KDM4EASPHKDM8RIOX2KDM4C | |
| SCHEMBL1715565 | 0.78 | ALDH1A1 (0.57) | KDM4EASPHKDM8RIOX2KDM4C | |
| SCHEMBL28663574 | 0.78 | KDM4E (0.58) | KDM4EASPHKDM8RIOX2HDAC1 | |
| SCHEMBL30358579 | 0.78 | KDM4E (0.58) | KDM4EASPHKDM8RIOX2HDAC1 | |
| SCHEMBL5627204 | 0.77 | ALDH1A1 (0.52) | KDM4EASPHKDM8RIOX2KDM4C | |
| SCHEMBL22836927 | 0.77 | AKR1C3 (0.63) | KDM4EASPHKDM8RIOX2KDM4C | |
| SCHEMBL22140401 | 0.76 | JAK3 (0.51) | KDM4EASPHKDM8RIOX2KDM4C | |
| SCHEMBL24157190 | 0.76 | KDM4E (0.65) | KDM4EASPHKDM8RIOX2KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012098066-A1 | 1,6- AND 1,8-NAPHTHYRIDINES USEFUL AS DYRK1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |
| US-20120184562-A1 | 1,6- AND 1,8-NAPHTHYRIDINES | LUK KIN-CHUN (US) | 2012-07-19 | — | — | US | disclosed |
| US-20120184562-A1 | 1,6- AND 1,8-NAPHTHYRIDINES | LUK KIN-CHUN (US) | 2012-07-19 | — | — | US | disclosed |
| US-20120184562-A1 | 1,6- AND 1,8-NAPHTHYRIDINES | LUK KIN-CHUN (US) | 2012-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120184562-A1 | 1,6- AND 1,8-NAPHTHYRIDINES | PSEN1, BRCA1, PSEN2 | KDM4E 2930/4885ASPH 794/4885KDM8 3751/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.