SCHEMBL10323009

SCHEMBL10323009

COc1c(Cl)cc(C(=O)N2CS(=O)(=O)c3ccccc32)cc1I

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC22A12 Q96S37 10/20 0.69
CYP2C9 P11712 2/20 0.66
ABCG2 Q9UNQ0 1/20 0.66
LMNA P02545 2/20 0.39
TAS1R3 Q7RTX0 1/20 0.37
TAS1R1 Q7RTX1 1/20 0.37
TAS1R2 Q8TE23 1/20 0.37
TUBB4A P04350 1/20 0.37
TUBB P07437 1/20 0.37
TUBA3C P0DPH7 1/20 0.37
TUBA1B P68363 1/20 0.37
TUBA4A P68366 1/20 0.37
TUBB4B P68371 1/20 0.37
TUBB3 Q13509 1/20 0.37
TUBB2A Q13885 1/20 0.37
TUBB8 Q3ZCM7 1/20 0.37
TUBA3E Q6PEY2 1/20 0.37
TUBA1A Q71U36 1/20 0.37
TUBA1C Q9BQE3 1/20 0.37
TUBB6 Q9BUF5 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10322864 0.92 SLC22A12 (0.76) SLC22A12CYP2C9ABCG2LMNATAS1R3
SCHEMBL10323032 0.87 SLC22A12 (0.72) SLC22A12CYP2C9ABCG2LMNATUBB4A
SCHEMBL10322430 0.85 SLC22A12 (0.76) SLC22A12CYP2C9ABCG2LMNATAS1R3
SCHEMBL10323573 0.84 SLC22A12 (0.65) SLC22A12CYP2C9ABCG2LMNA
SCHEMBL10323647 0.84 SLC22A12 (0.74) SLC22A12CYP2C9ABCG2LMNATUBB4A
SCHEMBL10323650 0.84 SLC22A12 (0.65) SLC22A12CYP2C9ABCG2LMNATSHR
SCHEMBL10321901 0.84 SLC22A12 (0.62) SLC22A12CYP2C9ABCG2LMNATSHR
SCHEMBL10323732 0.84 SLC22A12 (0.84) SLC22A12CYP2C9ABCG2HSD11B1
SCHEMBL31582634 0.83 SLC22A12 (0.70) SLC22A12CYP2C9ABCG2LMNAHTT
SCHEMBL28004025 0.83 SLC22A12 (0.63) SLC22A12CYP2C9ABCG2LMNATUBB4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2484669-B1 PHENOL DERIVATIVES FUJI YAKUHIN CO LTD (JP) 2015-07-29 EP disclosed
US-8367843-B2 Phenol derivative FUJI YAKUHIN CO., LTD. (JP) 2013-02-05 US disclosed
CN-102639518-A Novel Phenol Derivatives FUJI YAKUHIN CO LTD 2012-08-15 CN disclosed
EP-2484669-A1 NOVEL PHENOL DERIVATIVE Fuji Yakuhin Co., Ltd. (JP) 2012-08-08 EP disclosed
US-20120184587-A1 NOVEL PHENOL DERIVATIVE FUJI YAKUHIN CO., LTD. (JP) 2012-07-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120184587-A1 NOVEL PHENOL DERIVATIVE XDH, REN, UTS2R SLC22A12 379/4885CYP2C9 184/4885ABCG2 5/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.