Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 10/20 | 0.55 |
| ▸ | MTOR | P42345 | 7/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | PIK3R1 | P27986 | 6/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10322861 | 0.82 | KCNK2 (0.49) | KMT2APTPN11ALDH1A1HSD17B10MAPK1 | |
| SCHEMBL24196192 | 0.76 | KDM4E (0.69) | PIK3CAMTORPIK3CDPIK3CBKMT2A | |
| SCHEMBL245017 | 0.76 | ALDH1A1 (0.63) | PIK3CAMTORPIK3CDPIK3CBKMT2A | |
| SCHEMBL21121002 | 0.76 | KMT2A (0.58) | PIK3CAMTORPIK3CDPIK3CBKMT2A | |
| SCHEMBL26647400 | 0.76 | PIK3CA (0.56) | PIK3CAMTORPIK3CDPIK3CBKMT2A | |
| SCHEMBL31254440 | 0.75 | NPC1 (0.58) | KMT2AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL245978 | 0.75 | PTPN11 (0.69) | PIK3CAPIK3CDPIK3CBKMT2APTPN11 | |
| SCHEMBL8191281 | 0.74 | POLB (0.57) | PIK3CAMTORPIK3CDPIK3CBKDM4E | |
| SCHEMBL10998627 | 0.73 | PIK3CA (0.52) | PIK3CAMTORPIK3CDPIK3CBKMT2A | |
| SCHEMBL1461650 | 0.73 | PIK3CA (0.54) | PIK3CAMTORPIK3CDPIK3CBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012098065-A1 | PYRIDO PYRIMIDINES FOR USE AS DYRK1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |
| US-20120184542-A1 | PYRIDO PYRIMIDINES | ANDERSON KEVIN (US) | 2012-07-19 | — | — | US | disclosed |
| US-20120184542-A1 | PYRIDO PYRIMIDINES | ANDERSON KEVIN (US) | 2012-07-19 | — | — | US | disclosed |
| US-20120184542-A1 | PYRIDO PYRIMIDINES | ANDERSON KEVIN (US) | 2012-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120184542-A1 | PYRIDO PYRIMIDINES | TYMS, TYMP, DPYD | PIK3CA 337/4885MTOR 2215/4885PIK3CD 665/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.