Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.44 |
| ▸ | CCR1 | P32246 | 2/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | SPR | P35270 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10325019 | 0.83 | SCN9A (0.61) | SCN9A | |
| SCHEMBL10324080 | 0.82 | L3MBTL1 (0.45) | SCN9ACCR1POLBLMNAMAPT | |
| SCHEMBL732578 | 0.81 | KDM4E (0.57) | FGFR1KDM4EALDH1A1POLBHPGD | |
| SCHEMBL31633025 | 0.81 | KMT2A (0.47) | SCN9ACCR1FGFR1CYP11B1CYP11B2 | |
| SCHEMBL30204949 | 0.80 | KDM4E (0.44) | SCN9AFGFR1DYRK1AKDM4EALDH1A1 | |
| SCHEMBL30864300 | 0.80 | KDM4E (0.44) | SCN9AFGFR1DYRK1AKDM4EALDH1A1 | |
| SCHEMBL31632785 | 0.77 | SPR (0.48) | SCN9AFGFR1KDM4EALDH1A1POLB | |
| SCHEMBL31633048 | 0.76 | KMT2A (0.48) | SCN9AFGFR1KDM4EPOLBLMNA | |
| SCHEMBL18561359 | 0.73 | ADORA2A (0.47) | FGFR1DYRK1AKDM4EALDH1A1HPGD | |
| SCHEMBL23535748 | 0.72 | KDM4E (0.43) | FGFR1DYRK1AKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012095781-A1 | INDAZOLE DERIVATIVES AS SODIUM CHANNEL INHIBITORS | PFIZER LIMITED (GB) | 2012-07-19 | — | — | WO | disclosed |
| WO-2012095781-A1 | INDAZOLE DERIVATIVES AS SODIUM CHANNEL INHIBITORS | PFIZER LIMITED (GB) | 2012-07-19 | — | — | WO | disclosed |