Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 2/20 | 0.36 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD5 | P21918 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.35 |
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL913181 | 0.80 | NPC1 (0.49) | ALDH1A1L3MBTL1NPC1DRD1DRD2 | |
| SCHEMBL16835810 | 0.75 | MAPT (0.44) | MAPTNPC1 | |
| SCHEMBL1356310 | 0.74 | ALDH1A1 (0.44) | ALDH1A1L3MBTL1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL10324759 | 0.74 | KDM4E (0.54) | MAPTALDH1A1L3MBTL1NPC1METAP2 | |
| SCHEMBL6018826 | 0.73 | CYP11B1 (0.47) | ALDH1A1L3MBTL1NPC1KDM4ESMN1; SMN2 | |
| SCHEMBL2004558 | 0.73 | IDO1 (0.42) | MAPTALDH1A1NPC1METAP2KDM4E | |
| SCHEMBL5963839 | 0.73 | KMO (0.43) | ALDH1A1L3MBTL1METAP2KDM4EPOLB | |
| SCHEMBL31607177 | 0.72 | ALDH1A1 (0.43) | ALDH1A1L3MBTL1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL31607175 | 0.72 | ALDH1A1 (0.43) | ALDH1A1L3MBTL1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL31607172 | 0.72 | ALDH1A1 (0.43) | ALDH1A1L3MBTL1KDM4ESMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012096813-A1 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-07-19 | — | — | WO | disclosed |