Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 17/20 | 0.76 |
| ▸ | SCN5A | Q14524 | 12/20 | 0.43 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SCN4A | P35499 | 1/20 | 0.42 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 2/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10325316 | 0.89 | SCN9A (0.62) | SCN9ASCN5ACYP2C8CYP2C9CYP2B6 | |
| SCHEMBL10324574 | 0.87 | SCN9A (0.59) | SCN9ASCN5ACYP2C8CYP2C9CYP2B6 | |
| Pf-05241328 SCHEMBL30275387 | 0.86 | SCN9A (1.00) | SCN9ASCN5ACYP2C8CYP2C9CYP2B6 | |
| Pf-05241328 SCHEMBL10324699 | 0.86 | SCN9A (1.00) | SCN9ASCN5ACYP2C8CYP2C9CYP2B6 | |
| SCHEMBL22484359 | 0.84 | SCN9A (0.83) | SCN9ASCN5ACYP2C8CYP2C9CYP2B6 | |
| SCHEMBL10380265 | 0.84 | SCN9A (0.82) | SCN9ASCN5ACYP2C8CYP2C9CYP2B6 | |
| SCHEMBL10380147 | 0.83 | SCN9A (0.81) | SCN9ASCN5ACYP2C8CYP2C9CYP2B6 | |
| SCHEMBL10324577 | 0.83 | SCN9A (0.59) | SCN9ASCN5ACYP2C9 | |
| SCHEMBL10325203 | 0.82 | SCN9A (0.54) | SCN9ASCN5ARORCSLC22A12 | |
| SCHEMBL10324674 | 0.80 | SCN9A (0.62) | SCN9ASCN5ACYP2C8CYP2C9CYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012095781-A1 | INDAZOLE DERIVATIVES AS SODIUM CHANNEL INHIBITORS | PFIZER LIMITED (GB) | 2012-07-19 | — | — | WO | disclosed |
| WO-2012095781-A1 | INDAZOLE DERIVATIVES AS SODIUM CHANNEL INHIBITORS | PFIZER LIMITED (GB) | 2012-07-19 | — | — | WO | disclosed |