Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 9/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.31 |
| ▸ | SCN2B | O60939 | 1/20 | 0.31 |
| ▸ | SCN1A | P35498 | 1/20 | 0.31 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10324714 | 0.83 | NR3C1 (0.39) | CYP11B2CYP19A1CYP2C9CYP11B1NR3C1 | |
| SCHEMBL10380273 | 0.81 | SCN9A (0.39) | NR3C1SCN9ASCN2BSCN1ASCN1B | |
| SCHEMBL10378869 | 0.79 | OPRL1 (0.34) | OPRL1SCN9ASCN2BSCN1ASCN1B | |
| SCHEMBL31424394 | 0.67 | HTR1A (0.34) | — | |
| SCHEMBL20740547 | 0.65 | KDM4E (0.42) | NR3C1EGFR | |
| SCHEMBL29989036 | 0.62 | OPRL1 (0.40) | OPRL1DRD2DRD4DRD3GRM2 | |
| SCHEMBL15599220 | 0.62 | OPRL1 (0.40) | OPRL1DRD2DRD4DRD3GRM2 | |
| SCHEMBL18335167 | 0.62 | PLAU (0.41) | OPRL1SCN9ASCN2BSCN1ASCN1B | |
| SCHEMBL29989135 | 0.58 | OPRL1 (0.41) | OPRL1TRPV1SCN9ASCN2BSCN1A | |
| SCHEMBL19075542 | 0.58 | OPRL1 (0.40) | OPRL1DRD2DRD4DRD3GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012095781-A1 | INDAZOLE DERIVATIVES AS SODIUM CHANNEL INHIBITORS | PFIZER LIMITED (GB) | 2012-07-19 | — | — | WO | disclosed |
| WO-2012095781-A1 | INDAZOLE DERIVATIVES AS SODIUM CHANNEL INHIBITORS | PFIZER LIMITED (GB) | 2012-07-19 | — | — | WO | disclosed |