Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.37 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10180630 | 0.90 | SMN1; SMN2 (0.44) | KDM4ETRPV4SMN1; SMN2SYKRXFP1 | |
| SCHEMBL10327185 | 0.88 | TRPV4 (0.41) | KDM4ETRPV4SMN1; SMN2TP53LMNA | |
| SCHEMBL10327383 | 0.86 | KDM4E (0.42) | KDM4ETRPV4SMN1; SMN2SYKRXFP1 | |
| SCHEMBL10327352 | 0.84 | TRPV4 (0.41) | KDM4ETRPV4SMN1; SMN2RXFP1LMNA | |
| SCHEMBL10327259 | 0.83 | TRPV4 (0.49) | TRPV4LMNAKMT2A | |
| SCHEMBL10327543 | 0.83 | HDAC4 (0.37) | TRPV4SMN1; SMN2TP53ALDH1A1MEN1 | |
| SCHEMBL10327123 | 0.83 | TRPV4 (0.39) | KDM4ETRPV4SMN1; SMN2RXFP1ALDH1A1 | |
| SCHEMBL10327476 | 0.82 | SMN1; SMN2 (0.45) | KDM4ESMN1; SMN2TP53LMNAGAA | |
| SCHEMBL3459376 | 0.81 | SMN1; SMN2 (0.46) | KDM4ETRPV4SMN1; SMN2SYKRXFP1 | |
| SCHEMBL964825 | 0.81 | SMN1; SMN2 (0.46) | KDM4ETRPV4SMN1; SMN2SYKRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | disclosed |