Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 15/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CASR | P41180 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10327385 | 0.91 | LMNA (0.46) | TRPV4EPHX2KMT2ACASRLMNA | |
| SCHEMBL12946848 | 0.91 | TRPV4 (0.48) | TRPV4EPHX2KMT2ACASRLMNA | |
| SCHEMBL10181357 | 0.87 | TRPV4 (0.47) | TRPV4EPHX2KMT2ACASR | |
| SCHEMBL10327185 | 0.84 | TRPV4 (0.41) | TRPV4KMT2ALMNA | |
| SCHEMBL10327145 | 0.83 | KDM4E (0.43) | TRPV4KMT2ALMNA | |
| SCHEMBL12946845 | 0.82 | TRPV4 (0.44) | TRPV4EPHX2KMT2ALMNA | |
| SCHEMBL12946852 | 0.81 | TRPV4 (0.47) | TRPV4EPHX2KMT2A | |
| SCHEMBL10327543 | 0.81 | HDAC4 (0.37) | TRPV4KMT2A | |
| SCHEMBL10327373 | 0.80 | LMNA (0.46) | TRPV4EPHX2KMT2ACASRLMNA | |
| SCHEMBL10327123 | 0.80 | TRPV4 (0.39) | TRPV4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | disclosed |