Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KDR | P35968 | 4/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.39 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL967392 | 0.87 | LMNA (0.53) | LMNAALDH1A1MAPTNPC1GAA | |
| SCHEMBL10327389 | 0.84 | LMNA (0.55) | LMNAALDH1A1MAPTNPC1GAA | |
| SCHEMBL963926 | 0.78 | ALDH1A1 (0.48) | LMNAALDH1A1MAPTNPC1GAA | |
| SCHEMBL964493 | 0.74 | ALDH1A1 (0.51) | LMNAALDH1A1MAPTGAASMN1; SMN2 | |
| SCHEMBL10327490 | 0.72 | ALDH1A1 (0.53) | LMNAALDH1A1MAPTSMN1; SMN2KDR | |
| SCHEMBL3460054 | 0.71 | SMN1; SMN2 (0.44) | LMNAALDH1A1MAPTNPC1GAA | |
| SCHEMBL963272 | 0.71 | SMN1; SMN2 (0.47) | LMNAALDH1A1MAPTGAASMN1; SMN2 | |
| SCHEMBL3460056 | 0.70 | SMN1; SMN2 (0.40) | LMNAALDH1A1MAPTNPC1GAA | |
| SCHEMBL10327088 | 0.69 | SMN1; SMN2 (0.47) | LMNAALDH1A1MAPTNPC1GAA | |
| SCHEMBL10327209 | 0.69 | SMN1; SMN2 (0.47) | LMNAALDH1A1MAPTNPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | disclosed |