Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 17/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 14/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.44 |
| ▸ | RPS27 | P42677 | 4/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.41 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.41 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.41 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | POLQ | O75417 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12947079 | 0.90 | MAPK8 (0.45) | MAPK8MAPK9PRKD3MAPK10RPS27 | |
| SCHEMBL10327289 | 0.88 | MAPK8 (0.43) | MAPK8MAPK9PRKD3MAPK10RPS27 | |
| SCHEMBL12946926 | 0.87 | MAPK8 (0.42) | MAPK8MAPK9PRKD3MAPK10RPS27 | |
| SCHEMBL10327478 | 0.82 | ALDH1A1 (0.42) | MAPK8MAPK9PRKD3MAP4K4MAP4K2 | |
| SCHEMBL13125779 | 0.80 | MAPK8 (0.38) | MAPK8MAPK9PRKD3MAPK10ALDH1A1 | |
| SCHEMBL12946909 | 0.80 | ALDH1A1 (0.41) | MAPK8MAPK9ALDH1A1 | |
| SCHEMBL10327120 | 0.78 | SMN1; SMN2 (0.42) | TP53ALDH1A1 | |
| SCHEMBL12946855 | 0.77 | NPC1 (0.40) | ALDH1A1 | |
| SCHEMBL10327539 | 0.76 | MAPK8 (0.51) | MAPK8MAPK9PRKD3MAPK10RPS27 | |
| SCHEMBL12947039 | 0.76 | MAPK8 (0.38) | MAPK8MAPK9PRKD3MAPK10RPS27 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | disclosed |