Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | XBP1 | P17861 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10327153 | 0.90 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL966073 | 0.90 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL964028 | 0.89 | LMNA (0.44) | SMN1; SMN2ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL10327463 | 0.89 | LMNA (0.46) | SMN1; SMN2ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL968748 | 0.88 | KMT2A (0.57) | SMN1; SMN2ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL965578 | 0.87 | ALDH1A1 (0.44) | SMN1; SMN2ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL967167 | 0.87 | ALDH1A1 (0.47) | SMN1; SMN2ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL965219 | 0.87 | ALDH1A1 (0.47) | SMN1; SMN2ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL967168 | 0.87 | ALDH1A1 (0.47) | SMN1; SMN2ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL965577 | 0.87 | ALDH1A1 (0.44) | SMN1; SMN2ALDH1A1LMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | disclosed |