Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | TP53 | P04637 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL966826 | 0.91 | KMT2A (0.61) | MAPTSMN1; SMN2LMNATP53HPGD | |
| SCHEMBL10327084 | 0.88 | LMNA (0.52) | MAPTSMN1; SMN2LMNATP53HPGD | |
| SCHEMBL964265 | 0.80 | KMT2A (0.78) | MAPTSMN1; SMN2LMNATP53HPGD | |
| SCHEMBL10327510 | 0.79 | LMNA (0.55) | MAPTSMN1; SMN2LMNATP53HPGD | |
| SCHEMBL8788041 | 0.72 | ALDH1A1 (0.67) | MAPTSMN1; SMN2LMNATP53HPGD | |
| SCHEMBL964536 | 0.71 | KMT2A (0.61) | MAPTSMN1; SMN2LMNATP53HPGD | |
| SCHEMBL966531 | 0.71 | MAPT (0.46) | MAPTSMN1; SMN2LMNATP53HPGD | |
| SCHEMBL1007657 | 0.71 | LMNA (0.56) | MAPTSMN1; SMN2LMNATP53HPGD | |
| SCHEMBL966062 | 0.71 | MAPT (0.40) | MAPTSMN1; SMN2LMNATP53HPGD | |
| SCHEMBL968564 | 0.70 | KMT2A (0.61) | MAPTSMN1; SMN2LMNATP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | disclosed |