Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 11/20 | 0.51 |
| ▸ | KIT | P10721 | 3/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10328522 | 0.89 | AXL (0.54) | AXLKITABCB1ABCC1KEAP1 | |
| SCHEMBL10328519 | 0.88 | AXL (0.51) | AXLKITABCB1ABCC1 | |
| SCHEMBL10328520 | 0.87 | AXL (0.57) | AXLKITABCB1ABCC1 | |
| SCHEMBL10328493 | 0.86 | AXL (0.59) | AXLKITABCB1ABCC1MET | |
| SCHEMBL10328494 | 0.86 | AXL (0.53) | AXLKITABCB1ABCC1KDR | |
| SCHEMBL10328498 | 0.86 | AXL (0.68) | AXLKITABCB1ABCC1 | |
| SCHEMBL10328487 | 0.86 | AXL (0.57) | AXLKITABCB1ABCC1PDGFRA | |
| SCHEMBL10328489 | 0.84 | AXL (0.58) | AXLKITPDGFRAKDR | |
| SCHEMBL10328499 | 0.83 | AXL (0.52) | AXLMET | |
| SCHEMBL10328491 | 0.82 | AXL (0.55) | AXLKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262772-B1 | QUINOLINE DERIVATIVES AS AXL KINASE INHIBITORS | MAX PLANCK GESELLSCHAFT (DE) | 2012-07-18 | — | — | EP | disclosed |