Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 14/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 3/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13667521 | 0.88 | AXL (0.61) | AXLKIT | |
| SCHEMBL13667523 | 0.88 | AXL (0.59) | AXLKIT | |
| SCHEMBL10328506 | 0.86 | AXL (0.57) | AXL | |
| SCHEMBL10328481 | 0.86 | AXL (0.59) | AXLKITKDR | |
| SCHEMBL10328503 | 0.86 | AXL (0.59) | AXLKIT | |
| SCHEMBL10328498 | 0.85 | AXL (0.68) | AXLKIT | |
| SCHEMBL10328487 | 0.85 | AXL (0.57) | AXLKITPDGFRAKDR | |
| SCHEMBL10328479 | 0.85 | AXL (0.58) | AXLKIT | |
| SCHEMBL10328522 | 0.84 | AXL (0.54) | AXLKIT | |
| SCHEMBL10328520 | 0.84 | AXL (0.57) | AXLKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262772-B1 | QUINOLINE DERIVATIVES AS AXL KINASE INHIBITORS | MAX PLANCK GESELLSCHAFT (DE) | 2012-07-18 | — | — | EP | disclosed |