Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.47 |
| ▸ | ITK | Q08881 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | NHERF1 | O14745 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | F12 | P00748 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10330656 | 0.89 | GPR17 (0.54) | SMN1; SMN2NPC1RAB9AHTTKMT2A | |
| SCHEMBL10330642 | 0.77 | DAO (0.63) | SMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL13964393 | 0.76 | SORT1 (0.65) | NR1H4SMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL21639644 | 0.76 | CA12 (0.48) | NR1H4SMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL21674069 | 0.76 | MEN1 (0.47) | NR1H4SMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL14363294 | 0.75 | NPC1 (0.60) | NR1H4SMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL6168742 | 0.73 | NPC1 (0.66) | SMN1; SMN2NPC1RAB9ATP53F12 | |
| SCHEMBL30395353 | 0.73 | NPC1 (0.66) | SMN1; SMN2NPC1RAB9ATP53F12 | |
| SCHEMBL21639712 | 0.73 | MAOA (0.58) | SMN1; SMN2NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL7696259 | 0.73 | NR1H4 (0.56) | NR1H4SMN1; SMN2NPC1RAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120184562-A1 | 1,6- AND 1,8-NAPHTHYRIDINES | LUK KIN-CHUN (US) | 2012-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120184562-A1 | 1,6- AND 1,8-NAPHTHYRIDINES | PSEN1, BRCA1, PSEN2 | NR1H4 2490/4885SMN1; SMN2 23/4885NPC1 29/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.