Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 6/20 | 0.56 |
| ▸ | TOP2B | Q02880 | 6/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.54 |
| ▸ | CLK2 | P49760 | 1/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3720416 | 0.89 | TOP2A (0.58) | TOP2ATOP2BKCNH2KDM4EALDH1A1 | |
| SCHEMBL10330775 | 0.88 | KCNH2 (0.64) | TOP2ATOP2BKCNH2KDM4EALDH1A1 | |
| SCHEMBL13469793 | 0.88 | CYP3A4 (0.43) | TOP2ATOP2BKCNH2KDM4EALDH1A1 | |
| SCHEMBL4747731 | 0.88 | CYP3A4 (0.43) | TOP2ATOP2BKCNH2KDM4EALDH1A1 | |
| Fluoride SCHEMBL5142576 | 0.87 | TOP2A (0.56) | TOP2ATOP2BKCNH2KDM4EALDH1A1 | |
| SCHEMBL5142579 | 0.86 | TOP2A (0.55) | TOP2ATOP2BKCNH2KDM4EALDH1A1 | |
| SCHEMBL10330765 | 0.83 | TOP2A (0.69) | TOP2ATOP2BKCNH2KDM4EALDH1A1 | |
| SCHEMBL4747727 | 0.83 | KCNH2 (0.52) | TOP2ATOP2BKCNH2KDM4EALDH1A1 | |
| SCHEMBL965164 | 0.82 | KDM4E (0.67) | KCNH2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL965162 | 0.82 | KDM4E (0.67) | KCNH2KDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8222407-B2 | Mutilin derivative having heterocyclic aromatic ring carboxylic acid structure in substituent at 14-position | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2012-07-17 | — | — | US | disclosed |
| US-8222407-B2 | Mutilin derivative having heterocyclic aromatic ring carboxylic acid structure in substituent at 14-position | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2012-07-17 | — | — | US | disclosed |
| US-20100197909-A1 | MUTILIN DERIVATIVE HAVING HETEROCYCLIC AROMATIC RING CARBOXYLIC ACID STRUCTURE IN SUBTITUENT AT 14-POSITION | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2010-08-05 | — | — | US | disclosed |
| US-20100197909-A1 | MUTILIN DERIVATIVE HAVING HETEROCYCLIC AROMATIC RING CARBOXYLIC ACID STRUCTURE IN SUBTITUENT AT 14-POSITION | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2010-08-05 | — | — | US | disclosed |
| US-7732612-B2 | 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones | JANSSEN PHARMACEUTICA, N.V. (BE) | 2010-06-08 | — | — | US | disclosed |
| US-20090156577-A1 | 7-AMINO ALKYLIDENYL-HETEROCYCLIC QUINOLONES AND NAPHTHYRIDONES | JANSSEN PHARMACEUTICA NV (BE) | 2009-06-18 | — | — | US | disclosed |
| US-7179805-B2 | 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156577-A1 | 7-AMINO ALKYLIDENYL-HETEROCYCLIC QUINOLONES AND NAPHTHYRIDONES | NQO2, QRFPR, NQO1 | TOP2A 389/4885TOP2B 359/4885KCNH2 519/4885 |
| US-20100197909-A1 | MUTILIN DERIVATIVE HAVING HETEROCYCLIC AROMATIC RING CARBOXYLIC ACID STRUCTURE IN SUBTITUENT AT 14-POSITION | PELP1, MLN, SND1 | TOP2A 3897/4885TOP2B 4117/4885KCNH2 4321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.