Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 6/20 | 0.55 |
| ▸ | TOP2B | Q02880 | 6/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | CLK2 | P49760 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3720416 | 0.97 | TOP2A (0.58) | TOP2ATOP2BKCNH2ALDH1A1POLB | |
| Fluoride SCHEMBL5142576 | 0.95 | TOP2A (0.56) | TOP2ATOP2BKCNH2ALDH1A1POLB | |
| SCHEMBL3558935 | 0.87 | KDM4E (0.62) | TOP2ATOP2BKCNH2ALDH1A1POLB | |
| SCHEMBL10330779 | 0.86 | TOP2A (0.56) | TOP2ATOP2BKCNH2ALDH1A1POLB | |
| SCHEMBL7804258 | 0.85 | TOP2A (0.55) | TOP2ATOP2BKCNH2ALDH1A1POLB | |
| SCHEMBL8131531 | 0.84 | TOP2A (0.44) | TOP2ATOP2BKCNH2ALDH1A1POLB | |
| SCHEMBL8131420 | 0.84 | TOP2A (0.44) | TOP2ATOP2BKCNH2ALDH1A1POLB | |
| SCHEMBL7502599 | 0.84 | TOP2A (0.44) | TOP2ATOP2BKCNH2ALDH1A1POLB | |
| SCHEMBL9094282 | 0.84 | TOP2A (0.44) | TOP2ATOP2BKCNH2ALDH1A1POLB | |
| SCHEMBL4387133 | 0.84 | ADRB2 (0.44) | TOP2ATOP2BKCNH2ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7304050-B2 | Antibacterial agents | PFIZER INC. (US) | 2007-12-04 | — | — | US | disclosed |
| EP-1670793-A1 | ANTIBACTERIAL AGENTS | Warner-Lambert Company LLC (US) | 2006-06-21 | — | — | EP | disclosed |
| US-20050070523-A1 | Antibacterial agents | HAGEN SUSAN (US) | 2005-03-31 | — | — | US | disclosed |
| WO-2005026161-A1 | ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY LLC (US) | 2005-03-24 | — | — | WO | disclosed |
| EP-0610958-B1 | Intermediates in the preparation of 4-oxoquinoline-3-carboxylic acid derivatives | UBE INDUSTRIES (JP) | 2001-10-04 | — | — | EP | disclosed |
| US-5496951-A | 1-CYCLOPROPYL-6-FLUORO-8-FLUORINATED METHOXY COMPOUNDS INCLUDING BORON DIFLUORIDE CHELATE; CHEMICAL INTERMEDIATES AND ANTIBACTERIAL AGENTS | SANKYO COMPANY, LIMITED (JP) | 1996-03-05 | — | — | US | disclosed |
| US-5436367-A | 3, 4-difluorobenzoic acid derivatives | SANKO COMPANY, LIMITED (JP) | 1995-07-25 | — | — | US | disclosed |
| EP-0352123-B1 | 4-Oxoquinoline-3-carboxylic acid derivatives, their preparation and their use | UBE INDUSTRIES (JP) | 1995-01-18 | — | — | EP | disclosed |
| US-5348961-A | Antibacterial agents | SANKYO COMPANY LIMITED (JP) | 1994-09-20 | — | — | US | disclosed |
| EP-0610958-A2 | Intermediates in the preparation of 4-oxoquinoline-3-carboxylic acid derivatives | UBE INDUSTRIES, LTD. (JP) | 1994-08-17 | — | — | EP | disclosed |
| US-5073556-A | Bactericides | SANKYO COMPANY LIMITED (JP) | 1991-12-17 | — | — | US | disclosed |
| EP-0352123-A2 | 4-Oxoquinoline-3-carboxylic acid derivatives, their preparation and their use | UBE INDUSTRIES LIMITED (JP) | 1990-01-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070523-A1 | Antibacterial agents | MRPL21, ABCB11, NQO1 | TOP2A 28/4885TOP2B 54/4885KCNH2 2204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.