Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | TSHR | P16473 | 5/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.39 |
| ▸ | TERT | O14746 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | EGFR | P00533 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | NSD2 | O96028 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10333272 | 0.83 | ALDH1A1 (0.43) | ALDH1A1TSHRALOX15HSD17B10CRHR1 | |
| SCHEMBL190887 | 0.78 | ALDH1A1 (0.41) | ALDH1A1TSHRALOX15HSD17B10CRHR1 | |
| SCHEMBL21173494 | 0.72 | ALDH1A1 (0.53) | ALDH1A1TSHRALOX15HSD17B10CRHR1 | |
| SCHEMBL10333921 | 0.71 | MAPT (0.40) | ALDH1A1TSHRKDM4ETDP1MAPK1 | |
| SCHEMBL5640689 | 0.69 | CRHR1 (0.51) | ALDH1A1TSHRALOX15HSD17B10CRHR1 | |
| SCHEMBL10631846 | 0.67 | ALDH1A1 (0.46) | ALDH1A1TSHRALOX15HSD17B10CRHR1 | |
| SCHEMBL8644984 | 0.67 | CRHR1 (0.46) | ALDH1A1TSHRALOX15HSD17B10CRHR1 | |
| SCHEMBL3789309 | 0.67 | ALDH1A1 (0.46) | ALDH1A1TSHRALOX15HSD17B10CRHR1 | |
| SCHEMBL5640688 | 0.67 | ALDH1A1 (0.46) | ALDH1A1TSHRALOX15HSD17B10CRHR1 | |
| SCHEMBL3186890 | 0.66 | ALDH1A1 (0.58) | ALDH1A1TSHRALOX15HSD17B10APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4900751-A | 2-Pyridinyl-phenyl-sulphinyl-and-phenyl-thio-benzimidazoles having antiflammatory or gastic acid secretion inhibition activity | FISONS PLC (GB) | 1990-02-13 | — | — | US | disclosed |
| US-4851419-A | Certain 2-pyridinyl-phenylsulfinyl-benzoxazoles, the corresponding benzothiazoles or benzimidazoles having anti-inflammatory or gastric acid secretion inhibition activity | FISONS PLC (GB) | 1989-07-25 | — | — | US | disclosed |
| EP-0220053-A2 | Benzimidazoles, benzoxazoles, benzothiazoles and their production, formulation and use as gastric acid secretion inhibitors | FISONS plc (GB) | 1987-04-29 | — | — | EP | disclosed |