Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.37 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11207428 | 0.81 | ALOX15 (0.40) | ALOX15GAASMN1; SMN2ADRA2ACYP2D6 | |
| SCHEMBL10334214 | 0.77 | ALOX15 (0.48) | ALOX15GAASMN1; SMN2NOTUMLMNA | |
| SCHEMBL10334355 | 0.73 | ALOX15 (0.45) | ALOX15GAASMN1; SMN2NOTUMLMNA | |
| SCHEMBL3260382 | 0.71 | ABCG2 (0.44) | ALOX15SMN1; SMN2LMNAHTTADRA2A | |
| SCHEMBL1986826 | 0.70 | ALOX15 (0.44) | ALOX15GAASMN1; SMN2NOTUMLMNA | |
| SCHEMBL10334334 | 0.70 | ALOX15 (0.42) | ALOX15GAASMN1; SMN2LMNAKDM4E | |
| SCHEMBL8308888 | 0.69 | ALOX15 (0.43) | ALOX15GAASMN1; SMN2HTTKDM4E | |
| Hydrochloric Acid SCHEMBL10335958 | 0.69 | ALOX15 (0.43) | ALOX15GAASMN1; SMN2NOTUMLMNA | |
| SCHEMBL10335957 | 0.69 | ALOX15 (0.43) | ALOX15GAASMN1; SMN2NOTUMLMNA | |
| SCHEMBL10976290 | 0.69 | ALOX15 (0.43) | ALOX15GAASMN1; SMN2NOTUMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4948797-A | 2,2-disubstitued 2,3-dihydro-1,4-benzodioxin derivatives having hypotensive activity | ISTITUTO LUSO FARMACO D'ITALIA S.P.A. (IT) | 1990-08-14 | — | — | US | disclosed |
| EP-0367888-A1 | 2,2-Disubstituted 2,3-dihydro-1,4-benzodioxin derivatives having hypotensive activity | ISTITUTO LUSO FARMACO D'ITALIA S.p.A. (IT) | 1990-05-16 | — | — | EP | disclosed |