Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | APEX1 | P27695 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 5/20 | 0.36 |
| ▸ | RECQL | P46063 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10334355 | 0.83 | ALOX15 (0.45) | ALOX15MAPTKDM4EGAASMN1; SMN2 | |
| SCHEMBL10334528 | 0.73 | ADRA2A (0.39) | ALOX15ALDH1A1MAPTKDM4ECHRM2 | |
| SCHEMBL10334214 | 0.71 | ALOX15 (0.48) | ALOX15ALDH1A1MAPTKDM4EGAA | |
| SCHEMBL10334249 | 0.70 | ALOX15 (0.47) | ALOX15MAPTKDM4EGAASMN1; SMN2 | |
| SCHEMBL10334535 | 0.68 | ALOX15 (0.42) | ALOX15ALDH1A1MAPTKDM4EAPEX1 | |
| SCHEMBL6773566 | 0.67 | ALDH1A1 (0.45) | ALOX15ALDH1A1MAPTKDM4EAPEX1 | |
| SCHEMBL11506768 | 0.66 | SMN1; SMN2 (0.39) | ALOX15ALDH1A1MAPTKDM4EAPEX1 | |
| Hydrochloric Acid SCHEMBL10545348 | 0.66 | ALOX15 (0.40) | ALOX15GAASMN1; SMN2 | |
| SCHEMBL9692342 | 0.65 | ADRA1D (0.47) | ALOX15CHRM2CHRM1CHRM3SMN1; SMN2 | |
| SCHEMBL10807862 | 0.65 | ALOX15 (0.40) | ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4948797-A | 2,2-disubstitued 2,3-dihydro-1,4-benzodioxin derivatives having hypotensive activity | ISTITUTO LUSO FARMACO D'ITALIA S.P.A. (IT) | 1990-08-14 | — | — | US | disclosed |
| EP-0367888-A1 | 2,2-Disubstituted 2,3-dihydro-1,4-benzodioxin derivatives having hypotensive activity | ISTITUTO LUSO FARMACO D'ITALIA S.p.A. (IT) | 1990-05-16 | — | — | EP | disclosed |