Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DBH | P09172 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | WDR5 | P61964 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9838297 | 0.84 | MEN1 (0.51) | DBHL3MBTL1LMNAMEN1ALDH1A1 | |
| SCHEMBL9837718 | 0.83 | CYP11B1 (0.51) | DBHL3MBTL1LMNAMEN1ALDH1A1 | |
| SCHEMBL10578249 | 0.81 | LMNA (0.35) | DBHL3MBTL1LMNAMEN1ALDH1A1 | |
| SCHEMBL10337133 | 0.81 | NOTUM (0.37) | DBHALDH1A1CYP2D6CYP2C19HSP90AA1 | |
| SCHEMBL9836335 | 0.80 | ALDH1A1 (0.33) | ALDH1A1KMT2AHSP90AA1BRD4 | |
| SCHEMBL10595462 | 0.79 | TLR8 (0.34) | LMNAALDH1A1KMT2AHSP90AA1 | |
| SCHEMBL9400818 | 0.79 | DBH (0.44) | DBHL3MBTL1LMNACYP11B1CYP11B2 | |
| SCHEMBL3979622 | 0.79 | DBH (0.44) | DBHL3MBTL1LMNAMEN1ALDH1A1 | |
| SCHEMBL9838167 | 0.78 | DBH (0.48) | DBHL3MBTL1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL6348986 | 0.78 | HSD17B10 (0.51) | L3MBTL1MEN1ALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0125033-B1 | DOPAMINE-BETA-HYDROXYLASE INHIBITORS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-04-26 | — | — | EP | claimed |
| EP-0212066-B1 | INTERMEDIATES USEFUL IN THE PREPARATION OF DOPAMINE-BETA-HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1990-11-22 | — | — | EP | disclosed |
| EP-0288488-A4 | DOPAMINE- -HYDROXYLASE INHIBITORS | — | 1990-09-12 | — | — | EP | disclosed |
| EP-0125033-B1 | DOPAMINE-BETA-HYDROXYLASE INHIBITORS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-04-26 | — | — | EP | disclosed |
| EP-0308573-A2 | Intermediates useful in the preparation of dopamine-beta-hydroxylase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1989-03-29 | — | — | EP | disclosed |
| EP-0288488-A1 | DOPAMINE- -HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1988-11-02 | — | — | EP | disclosed |
| WO-1988001267-A1 | DOPAMINE-ss-HYDROXYLASE INHIBITORS | SMITHKLINE BECKMAN CORPORATION (US) | 1988-02-25 | — | — | WO | disclosed |