Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13955928 | 0.86 | PDE4B (0.55) | POLBALDH1A1HTTHPGDCYP1A2 | |
| SCHEMBL5514790 | 0.86 | KDM4E (0.50) | POLBALDH1A1HTTHPGDCYP1A2 | |
| SCHEMBL29277287 | 0.85 | POLB (0.47) | POLBALDH1A1HTTHPGDCYP1A2 | |
| SCHEMBL4770411 | 0.84 | KDM4E (0.50) | ALDH1A1HTTHPGDCYP1A2CYP3A4 | |
| SCHEMBL8882021 | 0.82 | PDE10A (0.52) | ALDH1A1HTTHPGDCYP1A2CYP3A4 | |
| SCHEMBL28851842 | 0.81 | ALDH1A1 (0.40) | ALDH1A1HTTHPGDCYP1A2CYP3A4 | |
| SCHEMBL16533517 | 0.79 | LMNA (0.52) | POLBALDH1A1HTTCYP3A4SMN1; SMN2 | |
| SCHEMBL3880885 | 0.79 | LMNA (0.46) | POLBALDH1A1HTTHPGDCYP1A2 | |
| SCHEMBL14472404 | 0.78 | HTT (0.51) | ALDH1A1HTTHPGDCYP1A2CYP3A4 | |
| SCHEMBL29454737 | 0.77 | ALDH1A1 (0.45) | POLBALDH1A1HTTHPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105130954-A | 3,4-disubstituted-6-pyridylquinoline compound as well as preparation and application thereof | UNIV ZHEJIANG | 2015-12-09 | — | — | CN | disclosed |
| US-4965266-A | Antiallergens | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1990-10-23 | — | — | US | disclosed |
| EP-0298134-A1 | AROMATIC HETEROCYCLIC CARBOXYLIC ACID AMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | Dainippon Pharmaceutical Co., Ltd. (JP) | 1989-01-11 | — | — | EP | disclosed |