SCHEMBL10337489

SCHEMBL10337489

CCCCC1CNC(=O)N1CCO

nearest known ligand 0.57

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.45
MEN1 O00255 2/20 0.45
ALDH1A1 P00352 1/20 0.45
GAA P10253 2/20 0.33
GLA P06280 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
TP53 P04637 1/20 0.33
GBA1 P04062 1/20 0.33
NAAA Q02083 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8394535 0.86 GBA1 (0.43) KMT2AMEN1ALDH1A1GBA1NAAA
SCHEMBL10337442 0.86 GBA1 (0.43) KMT2AMEN1ALDH1A1GBA1NAAA
SCHEMBL3636070 0.85 MEN1 (0.43) KMT2AMEN1ALDH1A1GAAGLA
SCHEMBL8392269 0.83 MEN1 (0.42) KMT2AMEN1ALDH1A1GLATDP1
SCHEMBL3514840 0.79 MEN1 (0.36) KMT2AMEN1ALDH1A1GAAGLA
SCHEMBL20733168 0.75 GBA1 (0.44) KMT2AMEN1GAATDP1TP53
SCHEMBL6285666 0.73 KMT2A (0.39) KMT2AALDH1A1GLA
SCHEMBL9323763 0.72 CYP1A2 (0.38) KMT2AMEN1ALDH1A1NAAA
SCHEMBL18952911 0.72 CYP1A2 (0.38) KMT2AMEN1ALDH1A1NAAA
SCHEMBL10930342 0.72 PTGER2 (0.53)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0378657-A1 OXAZOLIDINONE PENETRATION ENHANCING COMPOUNDS. RAJADHYAKSHA VITHAL J 1990-07-25 EP disclosed
WO-1990000407-A1 OXAZOLIDINONE PENETRATION ENHANCING COMPOUNDS RAJADHYAKSHA VITHAL J (US) 1990-01-25 WO disclosed