Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Doxercalciferol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDR known ✓ | P11473 | 9/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.80 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.80 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.80 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.80 |
| ▸ | PGR | P06401 | 1/20 | 0.80 |
| ▸ | HTR1A | P08908 | 1/20 | 0.80 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.80 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.80 |
| ▸ | LMNA | P02545 | 2/20 | 0.77 |
| ▸ | AR | P10275 | 1/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.77 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.77 |
| ▸ | TSHR | P16473 | 1/20 | 0.77 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.77 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.77 |
| ▸ | USP2 | O75604 | 1/20 | 0.77 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.77 |
| ▸ | ESR1 | P03372 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Doxercalciferol SCHEMBL7152665 | 1.00 | VDR (1.00) | VDRADRA1AADORA3SLC6A2NR1I2 | |
| Doxercalciferol SCHEMBL322422 | 1.00 | VDR (1.00) | VDRADRA1AADORA3SLC6A2NR1I2 | |
| Doxercalciferol SCHEMBL15262963 | 1.00 | VDR (1.00) | VDRADRA1AADORA3SLC6A2NR1I2 | |
| Doxercalciferol SCHEMBL10018929 | 1.00 | VDR (1.00) | VDRADRA1AADORA3SLC6A2NR1I2 | |
| Doxercalciferol SCHEMBL3999503 | 1.00 | VDR (1.00) | VDRADRA1AADORA3SLC6A2NR1I2 | |
| Doxercalciferol SCHEMBL24066841 | 1.00 | VDR (1.00) | VDRADRA1AADORA3SLC6A2NR1I2 | |
| Doxercalciferol SCHEMBL285669 | 1.00 | VDR (1.00) | VDRADRA1AADORA3SLC6A2NR1I2 | |
| Doxercalciferol SCHEMBL9051060 | 1.00 | VDR (1.00) | VDRADRA1AADORA3SLC6A2NR1I2 | |
| Doxercalciferol SCHEMBL21433257 | 1.00 | VDR (1.00) | VDRADRA1AADORA3SLC6A2NR1I2 | |
| Doxercalciferol SCHEMBL9980508 | 1.00 | VDR (1.00) | VDRADRA1AADORA3SLC6A2NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2011563-A | — | — | None | — | — | JP | disclosed |
| JP-H0211563-A | PREPARATION OF 1BETA-HYDROXYVITAMIN D2 AND D3 | NISSHIN FLOUR MILLING CO LTD | 1990-01-16 | — | — | JP | disclosed |