Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Doxercalciferol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDR known ✓ | P11473 | 9/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.80 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.80 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.80 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.80 |
| ▸ | PGR | P06401 | 1/20 | 0.80 |
| ▸ | HTR1A | P08908 | 1/20 | 0.80 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.80 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.80 |
| ▸ | LMNA | P02545 | 2/20 | 0.77 |
| ▸ | AR | P10275 | 1/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.77 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.77 |
| ▸ | TSHR | P16473 | 1/20 | 0.77 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.77 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.77 |
| ▸ | USP2 | O75604 | 1/20 | 0.77 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.77 |
| ▸ | ESR1 | P03372 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Doxercalciferol SCHEMBL7152665 | 1.00 | VDR (1.00) | VDRADRA1AADORA3SLC6A2NR1I2 | |
| Doxercalciferol SCHEMBL10337669 | 1.00 | VDR (1.00) | VDRADRA1AADORA3SLC6A2NR1I2 | |
| Doxercalciferol SCHEMBL15262963 | 1.00 | VDR (1.00) | VDRADRA1AADORA3SLC6A2NR1I2 | |
| Doxercalciferol SCHEMBL10018929 | 1.00 | VDR (1.00) | VDRADRA1AADORA3SLC6A2NR1I2 | |
| Doxercalciferol SCHEMBL3999503 | 1.00 | VDR (1.00) | VDRADRA1AADORA3SLC6A2NR1I2 | |
| Doxercalciferol SCHEMBL24066841 | 1.00 | VDR (1.00) | VDRADRA1AADORA3SLC6A2NR1I2 | |
| Doxercalciferol SCHEMBL285669 | 1.00 | VDR (1.00) | VDRADRA1AADORA3SLC6A2NR1I2 | |
| Doxercalciferol SCHEMBL9051060 | 1.00 | VDR (1.00) | VDRADRA1AADORA3SLC6A2NR1I2 | |
| Doxercalciferol SCHEMBL21433257 | 1.00 | VDR (1.00) | VDRADRA1AADORA3SLC6A2NR1I2 | |
| Doxercalciferol SCHEMBL9980508 | 1.00 | VDR (1.00) | VDRADRA1AADORA3SLC6A2NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1041 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025122021-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFPEF), THROUGH TARGETING OF S100A9 AND CORRESPONDING DIMER PARTNER AND RECEPTORS | I3S - INSTITUTO DE INVESTIGAÇÃO E INOVAÇÃO EM SAÚDE, ASSOCIAÇÃO (PT) | 2025-06-12 | — | — | WO | claimed |
| US-11261257-B2 | Methods for detecting 1,25-dihydroxyvitamin D and related antibodies | DIASORIN S.P.A. (IT) | 2022-03-01 | — | — | US | claimed |
| EP-3650467-A1 | METHOD AND KIT FOR DETECTING 1,25-DIHYDROXYVITAMIN D AND RELATED ANTIBODIES | DiaSorin S.p.A. (IT) | 2020-05-13 | — | — | EP | claimed |
| US-10501548-B2 | Methods for detecting 1,25-dihydroxyvitamin D and related antibodies | DIASORIN S.P.A. (IT) | 2019-12-10 | — | — | US | claimed |
| CN-108969527-A | A kind of pharmaceutical preparation and its preparation method and application | 上海通用药业股份有限公司 | 2018-12-11 | — | — | CN | claimed |
| US-9913852-B2 | Method of treating and preventing secondary hyperparathyroidism | OPKO IRELAND GLOBAL HODLINGS, LTD. (KY) | 2018-03-13 | — | — | US | claimed |
| US-9402855-B2 | Method of treating and preventing secondary hyperparathyroidism | OPKO RENAL, LLC (US) | 2016-08-02 | — | — | US | claimed |
| US-20150361178-A1 | Method and Kit for Detecting 1,25-Dihydroxyvitamin D and Related Antibodies | DIASORIN S.P.A. (IT) | 2015-12-17 | — | — | US | claimed |
| US-20150335662-A1 | METHODS FOR DIAGNOSING AND TREATING SEPSIS | LOMA LINDA UNIVERSITY | 2015-11-26 | — | — | US | claimed |
| EP-2759550-A1 | Method and kit for detecting 1,25-dihydroxyvitamin D and related antibodies | DiaSorin S.p.A. (IT) | 2014-07-30 | — | — | EP | claimed |
| EP-0588539-A1 | Stabilized pharmaceutical compositions containing derivatives of vitamins D2 and D3 | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 1994-03-23 | — | — | EP | claimed |
| US-5104864-A | Administering alpha-hydroxy derivatives of vitamin D2 | BONE CARE INTERNATIONAL, INC. (US) | 1992-04-14 | — | — | US | claimed |
| EP-0198901-B1 | METHOD FOR PREPARING 1ALPHA-HYDROXYVITAMIN D COMPOUNDS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1992-03-18 | — | — | EP | claimed |
| EP-0401357-A1 | METHOD FOR IMPROVING REPRODUCTIVE FUNCTIONS IN MAMMALS. | WISCONSIN ALUMNI RES FOUND (US) | 1990-12-12 | — | — | EP | claimed |
| WO-1990006121-A2 | METHOD FOR IMPROVING REPRODUCTIVE FUNCTIONS IN MAMMALS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1990-06-14 | — | — | WO | claimed |
| EP-0198901-A4 | METHOD FOR PREPARING 1ALPHA-HYDROXYVITAMIN D COMPOUNDS. | WISCONSIN ALUMNI RES FOUND (US) | 1987-03-09 | — | — | EP | claimed |
| EP-0198901-A1 | METHOD FOR PREPARING 1ALPHA-HYDROXYVITAMIN D COMPOUNDS. | WISCONSIN ALUMNI RES FOUND (US) | 1986-10-29 | — | — | EP | claimed |
| WO-1986002648-A1 | METHOD FOR PREPARING 1alpha-HYDROXYVITAMIN D COMPOUNDS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1986-05-09 | — | — | WO | claimed |
| US-4225596-A | Method for treating calcium imbalance and improving calcium absorption in mammals | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1980-09-30 | — | — | US | claimed |
| US-4035493-A | Rodenticide | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1977-07-12 | — | — | US | claimed |