Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 5/20 | 0.47 |
| ▸ | HRH1 | P35367 | 11/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 10/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6273031 | 0.90 | HRH1 (0.59) | HTR3AHRH1CYP2D6KCNH2CHRM1 | |
| SCHEMBL9371586 | 0.87 | HRH1 (0.61) | HTR3AHRH1CYP2D6KCNH2CHRM1 | |
| SCHEMBL10337963 | 0.80 | HRH1 (0.67) | HTR3AHRH1CYP2D6KCNH2CHRM1 | |
| SCHEMBL5225964 | 0.76 | HRH1 (0.55) | HTR3AHRH1CYP2D6KCNH2CHRM1 | |
| SCHEMBL10337606 | 0.76 | HRH1 (0.77) | HTR3AHRH1CYP2D6KCNH2CHRM1 | |
| SCHEMBL22465480 | 0.75 | HTR3A (0.51) | HTR3AHRH1CYP2D6KCNH2CHRM1 | |
| SCHEMBL22465282 | 0.75 | HTR3A (0.51) | HTR3AHRH1CYP2D6KCNH2CHRM1 | |
| SCHEMBL22465278 | 0.75 | HTR3A (0.51) | HTR3AHRH1CYP2D6KCNH2CHRM1 | |
| SCHEMBL22465450 | 0.72 | HTR3A (0.56) | HTR3AHRH1CYP2D6KCNH2CHRM1 | |
| SCHEMBL22465452 | 0.72 | HTR3A (0.56) | HTR3AHRH1CYP2D6KCNH2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4912219-A | 2-[4-pyrimidin-2-yl amino)piperidin-1-yl]benzimidazole compound | SYNTHELABO (FR) | 1990-03-27 | — | — | US | disclosed |
| US-4820710-A | ANTIALLERGENS, ANTIHISTAMINES, ANTIINFLAMMATORY AGENTS | SYNTHELABO (FR) | 1989-04-11 | — | — | US | disclosed |